Recombinant Human MDK/Midkine Protein, N-His-SUMO

Description of Recombinant Human MDK/Midkine Protein, N-His-SUMO

Introduction to Recombinant Human MDK/Midkine Protein

Recombinant Human MDK/Midkine Protein, also known as Midkine, is a small heparin-binding growth factor that plays a crucial role in various biological processes, including cell growth, differentiation, and migration. It is a 13 kDa protein that is encoded by the MDK gene and is expressed in various tissues, including the brain, kidney, and liver. Recombinant Human MDK/Midkine Protein is a synthetic version of the naturally occurring protein, produced through recombinant DNA technology, and has been extensively studied for its potential therapeutic applications.

Structure of Recombinant Human MDK/Midkine Protein

Recombinant Human MDK/Midkine Protein is a homodimer, meaning it is composed of two identical subunits. Each subunit consists of 121 amino acids and contains two domains: an N-terminal domain and a C-terminal domain. The N-terminal domain is responsible for the heparin-binding activity of the protein, while the C-terminal domain is essential for its growth factor activity. The two subunits are held together by disulfide bonds, which are critical for the stability of the protein.

In addition to its primary structure, Recombinant Human MDK/Midkine Protein also has a unique tertiary structure. It forms a compact, globular structure, with the N-terminal domain forming a beta-sheet and the C-terminal domain forming an alpha-helix. This structure is crucial for the protein’s biological activity, as it allows it to interact with its receptors and other molecules in the body.

Activity of Recombinant Human MDK/Midkine Protein

Recombinant Human MDK/Midkine Protein has a wide range of biological activities, making it a versatile molecule with potential therapeutic applications. One of its main functions is to promote cell proliferation and survival. It does this by binding to its receptor, anaplastic lymphoma kinase (ALK), and activating downstream signaling pathways that stimulate cell growth and prevent cell death.

In addition to its role in cell growth, Recombinant Human MDK/Midkine Protein also plays a crucial role in cell migration. It helps cells move to different locations in the body by interacting with other proteins, such as integrins, which are involved in cell adhesion and movement. This activity is essential during embryonic development, wound healing, and tissue regeneration.

Furthermore, Recombinant Human MDK/Midkine Protein has been shown to have anti-inflammatory properties. It can inhibit the production of pro-inflammatory cytokines and promote the secretion of anti-inflammatory cytokines, making it a potential therapeutic agent for inflammatory diseases.

Application of Recombinant Human MDK/Midkine Protein

Due to its diverse biological activities, Recombinant Human MDK/Midkine Protein has been studied for its potential therapeutic applications in various diseases and conditions. Some of the key areas of research include cancer, cardiovascular diseases, and neurological disorders.

In cancer, Recombinant Human MDK/Midkine Protein has been shown to promote tumor growth and metastasis by stimulating cell proliferation and migration. Therefore, it is being investigated as a potential target for cancer therapy. On the other hand, in cardiovascular diseases, Recombinant Human MDK/Midkine Protein has shown promising results in promoting angiogenesis and tissue repair, making it a potential treatment for heart attack and stroke.

In neurological disorders, Recombinant Human MDK/Midkine Protein has been shown to have neuroprotective effects and promote nerve regeneration, making it a potential treatment for conditions such as spinal cord injury and neurodegenerative diseases.

Conclusion

In summary, Recombinant Human MDK/Midkine Protein is a small growth factor with diverse biological activities. Its structure, activity, and potential therapeutic applications make