Recombinant Human MUCL1/SBEM Protein, N-GST

Description of Recombinant Human MUCL1/SBEM Protein, N-GST

Introduction to Recombinant Human MUCL1/SBEM Protein

Recombinant Human MUCL1/SBEM Protein, also known as Mucin-like 1/Sperm-binding protein, is a type of recombinant protein that has been artificially produced through genetic engineering techniques. It is a glycoprotein that is involved in various biological processes and has potential applications in the field of medicine and research.

Structure of Recombinant Human MUCL1/SBEM Protein

Recombinant Human MUCL1/SBEM Protein is a large protein with a molecular weight of approximately 200 kDa. It is composed of 1,779 amino acids and contains multiple domains, including a mucin-like domain, a von Willebrand factor type D domain, and an EGF-like domain. The mucin-like domain is responsible for the protein’s high glycosylation, while the von Willebrand factor type D domain is involved in protein-protein interactions. The EGF-like domain is known to have a role in cell signaling.

The protein is heavily glycosylated, with approximately 50% of its molecular weight consisting of carbohydrates. This glycosylation is important for the protein’s stability and function. The glycosylation pattern of Recombinant Human MUCL1/SBEM Protein is similar to that of the native protein, making it a suitable replacement for the natural form.

Activity of Recombinant Human MUCL1/SBEM Protein

Recombinant Human MUCL1/SBEM Protein is primarily expressed in the reproductive tract, specifically in the epididymis and testis. It is involved in sperm-egg interactions and has been shown to play a role in fertilization. The protein is also expressed in the respiratory tract, where it is thought to protect against pathogens by binding to them and preventing their attachment to the respiratory epithelium.

Furthermore, Recombinant Human MUCL1/SBEM Protein has been found to have anti-inflammatory properties. It can inhibit the activation of immune cells and the production of pro-inflammatory cytokines, making it a potential therapeutic target for inflammatory diseases.

Application of Recombinant Human MUCL1/SBEM Protein

Due to its involvement in sperm-egg interactions, Recombinant Human MUCL1/SBEM Protein has potential applications in the field of assisted reproductive technology (ART). It can be used as a biomarker for male infertility, as well as a potential target for male contraceptive development. Studies have also shown that the protein is present in seminal fluid and may have a role in seminal plasma liquefaction, which is important for sperm motility.

In addition, Recombinant Human MUCL1/SBEM Protein has been investigated as a potential diagnostic and prognostic marker for certain types of cancer. High levels of the protein have been found in tumor tissues of lung, breast, and ovarian cancers, suggesting its potential as a biomarker for these diseases.

Furthermore, the anti-inflammatory properties of Recombinant Human MUCL1/SBEM Protein make it a promising candidate for the treatment of inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). It has been shown to reduce airway inflammation and improve lung function in animal models, making it a potential therapeutic agent for these conditions.

Conclusion

Recombinant Human MUCL1/SBEM Protein is a large glycoprotein with multiple domains and functions. Its involvement in sperm-egg interactions, anti-inflammatory properties, and potential as a biomarker for various diseases make it a valuable protein for both research and medical applications. With further studies and advancements in genetic engineering techniques, Recombinant Human MUCL1/SBEM Protein may have even more potential uses in the future.

Keywords: recombinant protein, antigen, MUCL1/SBEM Protein, glycoprotein, sperm