Recombinant Human PARVB Protein, N-His

Description of Recombinant Human PARVB Protein, N-His

Introduction to Recombinant Human PARVB Protein

Recombinant Human PARVB Protein, also known as Prostate Androgen-Regulated Protein, is a type of recombinant protein that plays a crucial role in various cellular processes. This protein is encoded by the PARVB gene and is a member of the parvin family of actin-binding proteins. It is involved in cell adhesion, migration, and signaling, making it an important protein in both normal and disease states. In this article, we will delve into the structure, activity, and applications of Recombinant Human PARVB Protein.

Structure of Recombinant Human PARVB Protein

Recombinant Human PARVB Protein is a 42 kDa protein consisting of 370 amino acids. It is composed of three domains: the N-terminal calponin homology (CH) domain, the central α-helical domain, and the C-terminal SH3 domain. The CH domain is responsible for binding to actin filaments, while the SH3 domain interacts with other proteins involved in cell signaling. The α-helical domain acts as a linker between the CH and SH3 domains, providing structural stability to the protein.

The crystal structure of Recombinant Human PARVB Protein has been determined, revealing a compact and globular shape with a high degree of flexibility. This allows the protein to interact with a variety of binding partners and perform its diverse functions in the cell.

Activity of Recombinant Human PARVB Protein

Recombinant Human PARVB Protein is primarily involved in cell adhesion and migration. It binds to the actin cytoskeleton and regulates its organization, which is essential for cell movement. It also interacts with other proteins, such as integrins and focal adhesion kinase, to form focal adhesions that connect the cell to the extracellular matrix. These interactions are crucial for cell adhesion and migration in processes such as wound healing and tissue development.

In addition to its role in cell adhesion, Recombinant Human PARVB Protein also plays a role in cell signaling. It has been shown to interact with various signaling molecules, including protein kinases and phosphatases, and modulate their activity. This suggests that Recombinant Human PARVB Protein may be involved in regulating important cellular pathways, such as cell proliferation and survival.

Applications of Recombinant Human PARVB Protein

Due to its involvement in various cellular processes, Recombinant Human PARVB Protein has potential applications in both research and medicine. In research, it can be used as a tool to study cell adhesion and migration, as well as the regulation of cell signaling pathways. Recombinant Human PARVB Protein can also be used to screen for potential drugs that target these processes.

In medicine, Recombinant Human PARVB Protein has been implicated in several diseases, including cancer and cardiovascular disease. It has been shown to be upregulated in prostate cancer, making it a potential biomarker for this type of cancer. Additionally, Recombinant Human PARVB Protein has been found to be involved in the development of atherosclerosis, suggesting it may be a therapeutic target for cardiovascular disease.

Furthermore, Recombinant Human PARVB Protein has been used in the development of diagnostic assays for various diseases, such as breast cancer and chronic kidney disease. Its ability to interact with other proteins and modulate their activity makes it a valuable tool for identifying disease biomarkers and potential drug targets.

Conclusion

In summary, Recombinant Human PARVB Protein is a versatile protein involved in cell adhesion, migration, and signaling. Its structure and activity make it an important player in various cellular processes, and its potential applications in research and medicine make it a valuable tool for understanding and treating diseases. Further research on Recombinant Human PARVB Protein is needed to fully understand its functions and potential therapeutic applications.