Recombinant Mouse Ccl6 Protein, N-His-SUMO

Description of Recombinant Mouse Ccl6 Protein, N-His-SUMO

Introduction to Recombinant Mouse Ccl6 Protein

Recombinant Mouse Ccl6 Protein, also known as Chemokine (C-C motif) ligand 6, is a small cytokine protein that plays a crucial role in the immune response and inflammation. It is a member of the C-C chemokine family and is produced by various cell types, including macrophages, fibroblasts, and endothelial cells. Recombinant Mouse Ccl6 Protein is a highly conserved protein, with a molecular weight of approximately 8 kDa.

Structure of Recombinant Mouse Ccl6 Protein

The structure of Recombinant Mouse Ccl6 Protein consists of 107 amino acids, with a conserved cysteine motif at the N-terminus and a highly conserved C-terminal region. It contains four cysteine residues, which form two disulfide bonds, giving it a characteristic tertiary structure. The protein also has a characteristic beta-sheet and alpha-helix secondary structure, which is essential for its function as a chemokine.

Activity of Recombinant Mouse Ccl6 Protein

Recombinant Mouse Ccl6 Protein acts as a chemoattractant for various immune cells, including monocytes, macrophages, dendritic cells, and T cells. It binds to the chemokine receptor CCR1, which is expressed on the surface of these cells, and induces their migration towards the site of inflammation or infection. This recruitment of immune cells is crucial for the initiation and progression of the immune response.

In addition to its chemotactic activity, Recombinant Mouse Ccl6 Protein also has pro-inflammatory properties. It can stimulate the production of pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α), by immune cells. This further amplifies the immune response and helps in the clearance of pathogens or damaged cells.

Application of Recombinant Mouse Ccl6 Protein

Recombinant Mouse Ccl6 Protein has various applications in both research and therapeutic settings. One of its primary uses is in the study of immune responses and inflammation. Its ability to induce the migration of immune cells makes it a valuable tool for investigating the role of these cells in different diseases, such as autoimmune disorders, allergies, and infections.

In therapeutic settings, Recombinant Mouse Ccl6 Protein has shown potential as an anti-cancer agent. Studies have demonstrated that it can inhibit the growth and metastasis of certain types of cancer cells, including breast and prostate cancer. This is due to its ability to induce the recruitment of immune cells, which can then target and destroy cancer cells.

Furthermore, Recombinant Mouse Ccl6 Protein has also been studied for its potential use in the treatment of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Its ability to stimulate the production of pro-inflammatory cytokines can be beneficial in these conditions, where the immune response is dysregulated.

Conclusion

Recombinant Mouse Ccl6 Protein is a vital cytokine in the immune system, with both chemotactic and pro-inflammatory properties. Its structure and activity make it an essential molecule in the initiation and progression of the immune response. Its diverse applications in research and therapy make it a valuable tool in understanding and treating various diseases. Further studies on Recombinant Mouse Ccl6 Protein may lead to the development of novel treatments for immune and inflammatory disorders.