Recombinant Mouse CD276/B7-H3 Protein, N-His

Description of Recombinant Mouse CD276/B7-H3 Protein, N-His

Introduction

The recombinant mouse CD276/B7-H3 protein is a highly versatile and potent antigen that has been extensively studied for its structural characteristics, activity, and potential applications in various fields of science. This protein is a member of the B7 family of immune checkpoint molecules and plays a crucial role in regulating immune responses.

Structure of Recombinant Mouse CD276/B7-H3 Protein

The recombinant mouse CD276/B7-H3 protein is a type I transmembrane protein with a molecular weight of approximately 60 kDa. It is composed of a single extracellular IgV-like domain, a transmembrane region, and a short cytoplasmic tail. The extracellular domain of CD276 contains two Ig-like domains, which are responsible for its binding to receptors on immune cells.

Activity of Recombinant Mouse CD276/B7-H3 Protein

The main function of recombinant mouse CD276/B7-H3 protein is to regulate T cell-mediated immune responses. It has been found to act as both a co-stimulatory and co-inhibitory molecule, depending on the context of the immune response. When expressed on antigen-presenting cells, CD276 interacts with its receptors on T cells, leading to the activation or suppression of T cell responses.

Moreover, CD276 has also been shown to have a role in tumor immune evasion. It is upregulated on the surface of tumor cells and can inhibit the activity of tumor-infiltrating T cells, thus promoting tumor growth. This makes CD276 an attractive target for cancer immunotherapy.

Applications of Recombinant Mouse CD276/B7-H3 Protein

The recombinant mouse CD276/B7-H3 protein has a wide range of potential applications in the field of immunology and cancer research. Its ability to regulate T cell responses makes it a promising target for the development of immunotherapies for various diseases. Some of the potential applications of this protein are:

• Cancer Immunotherapy: CD276 is highly expressed on the surface of various types of cancer cells, making it a potential target for cancer immunotherapy. Several studies have shown that targeting CD276 can enhance anti-tumor immune responses and inhibit tumor growth.
• Autoimmune Diseases: CD276 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Targeting this protein could potentially help in the treatment of these diseases by modulating immune responses.
• Infectious Diseases: CD276 has been shown to play a role in the immune response against certain infectious diseases, such as tuberculosis and HIV. Targeting this protein could potentially enhance immune responses and aid in the development of vaccines against these diseases.
• Diagnostic Tool: The recombinant mouse CD276/B7-H3 protein can also be used as a diagnostic tool for various diseases. Its expression on the surface of tumor cells can be used as a biomarker for cancer diagnosis, and its role in autoimmune diseases and infectious diseases can aid in disease diagnosis and monitoring.
• Research Tool: Recombinant mouse CD276/B7-H3 protein can also be used as a research tool to study the role of CD276 in various biological processes and diseases. Its ability to regulate immune responses makes it a valuable tool for studying the immune system and developing new therapies.

Conclusion

The recombinant mouse CD276/B7-H3 protein is a highly versatile and potent antigen that has a crucial role in regulating immune responses. Its unique structural characteristics and diverse functions make it a promising target for the development of immunotherapies for various diseases. With ongoing research, this protein is expected to have a significant impact on the fields of immunology and cancer research.