Recombinant Mouse TGFB1/TGF-beta-1 Protein, N-His

Description of Recombinant Mouse TGFB1/TGF-beta-1 Protein, N-His

Introduction

Recombinant Mouse TGFB1, also known as TGF-beta-1, is a protein that plays a crucial role in various biological processes such as cell growth, differentiation, and immune response. This protein is produced through genetic engineering techniques, making it a recombinant protein. In this article, we will explore the structure, activity, and application of Recombinant Mouse TGFB1 in detail.

Structure of Recombinant Mouse TGFB1

Recombinant Mouse TGFB1 is a homodimeric protein consisting of two identical subunits of 112 amino acids each. Each subunit has a molecular weight of approximately 12.5 kDa. The overall structure of this protein is similar to other members of the transforming growth factor-beta (TGF-beta) superfamily, with a cysteine knot motif formed by six conserved cysteine residues.

The active form of Recombinant Mouse TGFB1 is a disulfide-linked homodimer, where the two subunits are held together by a disulfide bond between cysteine residues at positions 33 and 88. This structure is essential for the biological activity of the protein.

Activity of Recombinant Mouse TGFB1

Recombinant Mouse TGFB1 is a multifunctional cytokine that regulates a wide range of cellular processes. It exerts its effects by binding to specific cell surface receptors and activating downstream signaling pathways. The primary receptor for TGFB1 is the TGF-beta type II receptor (TGFBR2), which then recruits and phosphorylates the TGF-beta type I receptor (TGFBR1). This results in the activation of downstream signaling pathways, including the Smad pathway, which regulates gene expression.

One of the key activities of Recombinant Mouse TGFB1 is its ability to inhibit cell proliferation. This is achieved by inducing cell cycle arrest and promoting cell differentiation. Additionally, TGFB1 has been shown to play a role in wound healing, tissue repair, and immune response. It can also regulate the production and function of various immune cells, such as T cells, B cells, and macrophages.

Application of Recombinant Mouse TGFB1

Recombinant Mouse TGFB1 has a wide range of applications in both research and therapeutic settings. One of the primary uses of this protein is in cell culture experiments. It is commonly used to study the effects of TGFB1 on various cell types and to investigate its role in different biological processes.

In the field of regenerative medicine, Recombinant Mouse TGFB1 has shown promising results in promoting tissue repair and regeneration. It has been used in various preclinical studies to enhance wound healing and tissue regeneration in different organs, including skin, bone, and cartilage.

Furthermore, Recombinant Mouse TGFB1 has been studied for its potential therapeutic benefits in various diseases. Due to its ability to regulate immune responses, it has been investigated as a potential treatment for autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. It has also shown promise in cancer therapy, as it can inhibit the growth and metastasis of certain types of cancers.

Conclusion

In summary, Recombinant Mouse TGFB1 is a vital protein with diverse functions in various biological processes. Its structure as a homodimer and its ability to activate downstream signaling pathways make it a potent regulator of cell growth and differentiation. Its applications in research and therapy make it a valuable tool in understanding and treating various diseases. With ongoing research and advancements in genetic engineering techniques, Recombinant Mouse TGFB1 holds great potential for future therapeutic applications.