TNFa / TNF-alpha, N-His, recombinant protein (E.coli)
Origin species
Homo sapiens (Human)
Expression system
Prokaryotic expression
Molecular weight
19.66 kDa
Protein delivered with Tag?
N-terminal His Tag
Purity estimated
>90% as determined by SDS-PAGE
Buffer
PBS, pH7.5
Delivery condition
Dry Ice
Storage condition
4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand
ProteoGenix
Host species
Escherichia coli (E.coli)
Fragment Type
Val77-Leu233
Protein Accession
P01375
Aliases /Synonyms
cachexin, cachectin
Reference
PX-P5960
Note
For research use only
Description of TNFa / TNF-alpha, N-His, recombinant protein (E.coli)
General information on TNFa / TNF-alpha, N-His, recombinant protein
TNF-alpha: Structure, Activity, and Application
TNF-alpha (tumor necrosis factor-alpha) is a cytokine protein produced by various cells in the body. It is a type of pro-inflammatory cytokine, meaning it plays an important role in the body’s immune response.
Structure
TNF-alpha is a homotrimeric glycoprotein composed of three identical subunits, each around 17 kDa in size. Each subunit is composed of an N-terminal signal peptide, a pro-region, and a mature region.
Activity
TNF-alpha is involved in a variety of cellular processes, including cell differentiation, apoptosis, and the regulation of immune responses. It binds to two distinct receptors, TNFR1 and TNFR2, and activates a variety of intracellular signaling pathways.
Application
TNF-alpha is a key mediator of inflammation, and has been implicated in a variety of diseases, including rheumatoid arthritis, psoriasis, and Crohn’s disease. As such, it has become a major target for therapeutic intervention. A number of TNF-alpha inhibitors have been developed for the treatment of these conditions.
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