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Brand: ProteoGenix

TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

Host species:
Escherichia coli (E.coli)
Origin species:
Homo sapiens (Human)
Uniprot ID:
P01375
Molecular weight:
19.66 kDa

$320.00

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His Val77–Leu233
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SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein
TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

Product name TNFa / TNF-alpha, N-His, recombinant protein (E.coli)
Uniprot ID P01375
Origin species Homo sapiens (Human)
Expression system Prokaryotic expression
Raw Antigen Sequence VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Molecular weight 19.66 kDa
Protein delivered with Tag? N-terminal His Tag
Purity estimated >90% as determined by SDS-PAGE
Buffer PBS, pH7.5
Delivery condition Dry Ice
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Escherichia coli (E.coli)
Fragment Type Val77-Leu233
Protein Accession P01375
Aliases /Synonyms cachexin, cachectin
Reference PX-P5960
Note For research use only
Molecular Constructor
His Val77–Leu233

General information on TNFa / TNF-alpha, N-His, recombinant protein

TNF-alpha: Structure, Activity, and Application

TNF-alpha (tumor necrosis factor-alpha) is a cytokine protein produced by various cells in the body. It is a type of pro-inflammatory cytokine, meaning it plays an important role in the body’s immune response.

Structure

TNF-alpha is a homotrimeric glycoprotein composed of three identical subunits, each around 17 kDa in size. Each subunit is composed of an N-terminal signal peptide, a pro-region, and a mature region.

Activity

TNF-alpha is involved in a variety of cellular processes, including cell differentiation, apoptosis, and the regulation of immune responses. It binds to two distinct receptors, TNFR1 and TNFR2, and activates a variety of intracellular signaling pathways.

Application

TNF-alpha is a key mediator of inflammation, and has been implicated in a variety of diseases, including rheumatoid arthritis, psoriasis, and Crohn’s disease. As such, it has become a major target for therapeutic intervention. A number of TNF-alpha inhibitors have been developed for the treatment of these conditions.

SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

TNFa / TNF-alpha, N-His, recombinant protein on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is superior than 90 %.

TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

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