Zanidatamab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb – Research Grade

Description of Zanidatamab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb - Research Grade

Introduction

Zanidatamab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb – Research Grade is a monoclonal antibody (mAb) that specifically targets the proteins ERBB2, EGFR2, and CD340. This biosimilar is a highly effective and promising therapeutic agent for the treatment of various cancers, particularly those that overexpress these proteins. In this article, we will discuss the structure, activity, and applications of Zanidatamab Biosimilar in detail.

Structure of Zanidatamab Biosimilar

Zanidatamab Biosimilar is a recombinant humanized IgG1 monoclonal antibody that is produced in Chinese hamster ovary (CHO) cells. It has a molecular weight of approximately 150 kDa and consists of two heavy and two light chains. The heavy chains are composed of four constant domains (CH1, CH2, CH3, and CH4) and one variable domain (VH), while the light chains contain one constant domain (CL) and one variable domain (VL). The variable domains of Zanidatamab Biosimilar are responsible for its high specificity and affinity towards its target proteins.

Activity of Zanidatamab Biosimilar

Zanidatamab Biosimilar specifically binds to the extracellular domains of ERBB2, EGFR2, and CD340 with high affinity. These proteins are known as receptor tyrosine kinases (RTKs) and are overexpressed in various cancers, including breast, ovarian, and lung cancers. The binding of Zanidatamab Biosimilar to these proteins inhibits their signaling pathways, leading to the inhibition of cell growth and proliferation. Moreover, Zanidatamab Biosimilar also induces antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which further enhances its anti- cancer activity.

Applications of Zanidatamab Biosimilar

Zanidatamab Biosimilar has shown promising results in preclinical and clinical studies for the treatment of various cancers. It has been granted orphan drug designation for the treatment of gastric and gastroesophageal junction cancers by the US Food and Drug Administration (FDA). Additionally, Zanidatamab Biosimilar is being evaluated in clinical trials for the treatment of breast, ovarian, and lung cancers. Its potential as a therapeutic agent for these cancers is due to its ability to target multiple proteins, which makes it effective against cancers that have developed resistance to other targeted therapies.

Future prospects

The development of biosimilars, such as Zanidatamab Biosimilar, has the potential to revolutionize cancer treatment by providing more affordable and accessible options for patients. The biosimilar market is expected to grow significantly in the coming years, and Zanidatamab Biosimilar is poised to be a major player in this market. Further research and clinical trials will provide more insights into its efficacy and safety, and it is expected to receive regulatory approval in the near future.

Conclusion

In conclusion, Zanidatamab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb – Research Grade is a highly specific and potent monoclonal antibody that targets multiple proteins involved in cancer development and progression. Its unique structure and activity make it a promising therapeutic agent for the treatment of various cancers, particularly those that overexpress ERBB2, EGFR2, and CD340. With ongoing research and clinical trials, Zanidatamab Biosimilar has the potential to improve the lives of many cancer patients and contribute to the advancement of cancer treatment.

SDS-PAGE for Zanidatamab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb

Zanidatamab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb on SDS-PAGE under non-reducing (left figure) and reducing (right figure) conditions. The gel was stained overnight with Coomassie Blue. The purity of the antibody is superior than 90 %.