Integrated Therapeutic Antibody Services

Looking to develop a new therapeutic antibody? Maximize your chances of identifying the best possible candidate to reach clinical phases thanks to ProteoGenix therapeutic antibody discovery services! By partnering with ProteoGenix, you gain access to comprehensive, turnkey solutions—from target production to bioproduction. Whether it’s generating human antibodies against complex targets (including membrane proteins in their native conformation), designing and producing antibody-drug conjugates, or developing stable cell lines capable of yielding titers of several grams per liter, we meet these challenges every day for biotech and biopharma clients of all sizes.

At ProteoGenix, we understand that bringing a therapeutic antibody discovery project to clinical phases requires meticulous attention to detail. That’s why we’ve designed comprehensive and customizable end-to-end solutions combining artificial intelligence with wet lab expertise to ensure your antibody perfectly aligns with your vision.

Our services cover every critical stage, from antigen production to the manufacturing of your lead candidate:

• Antigen design and production: peptides, soluble proteins, membrane proteins, haptens, DNA…
• 3 antibody discovery platforms for generating human lead candidates:
  • Phage display using human libraries (naïve and immune)
  • Single B cell screening on humanized mice
  • Hybridoma development in humanized mice
• Advanced lead optimization services: bispecific antibodies, ADCs, CAR-T development, humanization, affinity maturation, and developability improvement.
• Antibody production at all scales, tailored to each development phase:
  • High-throughput production for preliminary screening
  • Transient production for preclinical studies
  • Stable cell line development for clinical trials

At ProteoGenix, we combine an unmatched range of services with deep technical expertise to deliver fast, reliable, and tailored strategies for advancing your project to clinical stages. At every step, we provide in-depth characterizations to guide your decision-making and maximize your project’s success potential.

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Our Promise #1: Discover human antibodies against any target and pathology

With over 20 years of experience in antibody discovery and development, ProteoGenix has consistently pioneered innovative solutions for the design and production of complex targets, as well as for the discovery of human antibodies against them.

Get the best start with a well-designed antigen

Designing and producing your target are two of the most crucial steps in determining the success of your therapeutic antibody. This process requires antigen design in its native conformation. As experts in gene, peptide, and protein synthesis and expression, we are equipped to produce any type of antigen, including:

• Haptens
• Peptides
• Soluble proteins
• Membrane proteins in their native conformation
• Cells
• DNA

In addition to these three human antibody generation platforms, ProteoGenix also offers advanced nanobody discovery solutions.

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Our Promise #4: Make informed decisions with our antibody characterization platform

Taking your therapeutic antibody to clinical phases requires critical decision-making at key stages. To ensure you make the right choices, you need a world-class antibody characterization platform and guidance from therapeutic antibody development experts. Our platform provides detailed insights into the structural and functional properties of your biomolecules, including:

• Sequence
• Molecular weight
• Post-translational modifications
• Affinity to target (Kd)
• Stability, and more…

Find more detailed information on our antibody characterization platform on our dedicated page.

What does our therapeutic antibody discovery services include?

Core services

Our therapeutic antibody discovery service includes a tailored strategy based on your specifications, antigen design and production, and antibody generation, production, and purification, all according to the chosen method.

Additional services

As experts in therapeutic antibody development, ProteoGenix offers an array of additional services to bring your antibody through to early clinical phases. These can include:

• Lead candidate engineering: Conjugation to create an antibody-drug conjugate, development of a bispecific antibody or CAR-T, or enhancement of compound properties such as affinity maturation, humanization, and developability.
• Antibody production: Options include high-throughput production for screening multiple sequences, transient production for early preclinical testing, or stable cell line production for large-scale manufacturing.

The optimal strategy, with or without these additional services, will be developed in collaboration with one of our therapeutic antibody development experts. Have a project or questions? Feel free to contact us by clicking here.