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100ug, 1MG
ProteoGenix
Primary Antibodies, Therapeutic Antibodies
Monoclonal Antibody
Mammalian cells
Elisa, WB
Amivantamab is a bispecific monoclonal antibody with an enhanced FC-part. This antibody is part of the human immunoglobulin G1-kappa type. It is targeting epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor (MET, a receptor tyrosine kinase). Both of these factors have key roles in proto-oncogen pathways and invasive growth program.
As Amivantamab biosimilar is targeting proto-oncogen signaling pathway, it is known to have an antineoplasic activity. Janssen Biotech has recently obtained the first approval for RYBREVANT (amivantamab-vmjw –an injection for intravenous infusion) by FDA to treat non-small cell lung cancer (NSCLC) in some conditions. There are also preregistrations in the European Union, Switzerland, Japan, China, Canada and Australia. To be used as a treatment, patients should be adults “with locally advanced or metastatic NSCLC harbouring EGFR Exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy”, according to the FDA.
NSCLC is the most common kind of primary type of lung cancer(85% of lung cancers). This cancer is mostly treated using different types of therapy such as immunotherapy and targeted therapy. NSCLCs are carcinomas: this means that the cells developing invasive growth are located on the surface of all the airway parts (bronchi, bronchioles, and alveoli). Symptoms are especially including a chronic cough, chest pain and exhaustion.
Amivantamab biosimilar is the result of about ten years of research on cross Mab technology. It is produced in mammalian cell line (Chinese Hamster Ovary -CHO) using a recombinant DNA technology. Proteogenix offers this product for research use only.
Amivantamab Biosimilar - Anti-EGFR/ME/RCCP2 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.
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