Europe: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition
4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand
ProteoGenix
Host species
Mammalian cells
Fragment Type
Met1-Cys647
Aliases /Synonyms
TR,Gene associated with retinoic and interferon-induced mortality 12 protein,GRIM-12,Gene associated with retinoic and IFN-induced mortality 12 protein,KM-102-derived reductase-like factor,Thioredoxin reductase TR1,GRIM12, KDRF
Reference
PX-P4610
Note
For research use only
Description of Thioredoxin reductase 1, cytoplasmic(TXNRD1)(Mammalian cells production)
General Information about Thioredoxin reductase 1, cytoplasmic (TXNRD1)
Thioredoxin reductase 1 (cytoplasm) is an enzyme in humans encoded by the TXNRD1 gene, which encodes a member of the pyridine nucleotide oxidoreductase family. The protein can reduce thioredoxin and other substrates, and play a role in selenium metabolism and anti-oxidative stress. This functional enzyme is considered to be a homodimer using FAD as a cofactor. Each subunit contains selenocysteine (Sec), which is necessary for catalytic activity. Selenocysteine is encoded by the UGA codon which normally signals the termination of translation. The 3′ UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
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