Recombinant Human IFNG/IFN-gamma Protein, N-His

Description of Recombinant Human IFNG/IFN-gamma Protein, N-His

Introduction

Recombinant Human IFNG/IFN-gamma Protein is a highly versatile protein that plays a critical role in the immune response. It is a type II interferon, which is a group of proteins that are produced by the body in response to viral or bacterial infections. This protein is also known as interferon gamma and is encoded by the IFNG gene. Recombinant Human IFNG/IFN-gamma Protein is produced through genetic engineering techniques, making it a highly pure and potent protein with a wide range of applications in both research and therapeutic settings.

Structure of Recombinant Human IFNG/IFN-gamma Protein

Recombinant Human IFNG/IFN-gamma Protein is a homodimer, meaning it is composed of two identical subunits. Each subunit is made up of 143 amino acids and has a molecular weight of approximately 16.5 kDa. The protein has a three-dimensional structure that is stabilized by four disulfide bonds. It also contains several glycosylation sites, which are important for its stability and function.

Activity of Recombinant Human IFNG/IFN-gamma Protein

Recombinant Human IFNG/IFN-gamma Protein is a potent cytokine that plays a crucial role in the immune response. It is primarily produced by activated T cells and natural killer (NK) cells, but can also be produced by other immune cells such as macrophages and dendritic cells. This protein has both pro-inflammatory and immunomodulatory effects, making it a key player in the body’s defense against infections and tumors.

One of the main functions of Recombinant Human IFNG/IFN-gamma Protein is to activate macrophages and enhance their ability to kill pathogens. It also stimulates the production of other cytokines, such as TNF-alpha, IL-1, and IL-6, which further amplify the immune response. In addition, this protein can increase the expression of major histocompatibility complex (MHC) molecules on the surface of cells, making them more visible to the immune system.

Application of Recombinant Human IFNG/IFN-gamma Protein

Recombinant Human IFNG/IFN-gamma Protein has a wide range of applications in both research and therapeutic settings. In research, it is commonly used as a tool to study the immune response and its role in various diseases. This protein can be used to activate immune cells in vitro, allowing researchers to study their function and behavior.

In therapeutic settings, Recombinant Human IFNG/IFN-gamma Protein has been approved for the treatment of several diseases, including chronic granulomatous disease, osteopetrosis, and severe combined immunodeficiency (SCID). It has also shown promising results in the treatment of certain types of cancer, such as melanoma and renal cell carcinoma.

Recombinant Protein as an Antigen in Vaccine Development

Recombinant Human IFNG/IFN-gamma Protein has also been studied as a potential antigen in vaccine development. This protein can elicit a strong immune response and has been shown to enhance the efficacy of vaccines against viral and bacterial infections. It has also been explored as a potential adjuvant, which is a substance that can boost the immune response to a vaccine.

Conclusion

In summary, Recombinant Human IFNG/IFN-gamma Protein is a highly versatile protein with important roles in the immune response. Its structure, activity, and applications make it a valuable tool in both research and therapeutic settings. With ongoing research and development, this protein holds great potential for the treatment and prevention of various diseases.