Recombinant Human POU2F2, N-His

Description of Recombinant Human POU2F2, N-His

Introduction

Recombinant Human POU2F2, N-His is a protein that plays a crucial role in the regulation of gene expression. It belongs to the POU (Pit-Oct-Unc) family of transcription factors and is also known as Octamer-binding transcription factor 2 (OCT2). This protein is a drug target for several diseases and has potential applications in the field of medicine.

Structure of Recombinant Human POU2F2, N-His

Recombinant Human POU2F2, N-His is a 58 kDa protein consisting of 528 amino acids. It has a modular structure with two distinct domains – a POU-specific domain and a POU homeodomain. The POU-specific domain is responsible for DNA binding, while the POU homeodomain is involved in protein-protein interactions. This protein also contains a histidine (His) tag at the N-terminus, which is useful for purification purposes.

Activity of this protein

Recombinant Human POU2F2, N-His is a transcription factor that regulates the expression of various genes. It binds to specific DNA sequences and activates or represses the transcription of target genes. This protein is involved in the development and differentiation of various cell types, including immune cells, neurons, and muscle cells. It also plays a crucial role in maintaining the balance between cell proliferation and differentiation.

One of the key functions of Recombinant Human POU2F2, N-His is its involvement in the immune response. It regulates the expression of genes involved in the production of antibodies and cytokines, which are essential for fighting against infections and diseases. This protein also plays a role in the development and function of T cells, B cells, and natural killer cells.

Application of Recombinant Human POU2F2, N-His

Recombinant Human POU2F2, N-His has potential applications in the field of medicine. As a drug target, this protein is being studied for its role in various diseases, including cancer, autoimmune disorders, and viral infections. In cancer, POU2F2 has been found to be overexpressed in several types of tumors and is associated with tumor growth and metastasis. Targeting this protein could potentially inhibit tumor growth and improve treatment outcomes.

In autoimmune disorders, POU2F2 has been linked to the regulation of immune responses. It has been found to be dysregulated in diseases such as rheumatoid arthritis and multiple sclerosis. Targeting this protein could help in controlling the overactive immune response and provide relief to patients.

Recombinant Human POU2F2, N-His is also being studied for its potential in viral infections. It has been found to regulate the expression of genes involved in the immune response against viruses. Targeting this protein could potentially enhance the immune response and aid in the clearance of viral infections.

Conclusion

In conclusion, Recombinant Human POU2F2, N-His is a crucial protein involved in the regulation of gene expression. Its structure, activity, and potential applications make it an important drug target for various diseases. Further research and development of therapies targeting this protein could potentially lead to improved treatment options for patients.