Title: Introduction to Anti-Human CD41/ITGA2B & CD61/ITGB3 Antibody (PAC-1), PE
Anti-Human CD41/ITGA2B & CD61/ITGB3 Antibody (PAC-1), PE is a highly specific and sensitive antibody used in various research applications. This antibody targets the integrin subunits CD41 and CD61, also known as ITGA2B and ITGB3, respectively. These integrin subunits are found on the surface of platelets and play a crucial role in platelet aggregation and adhesion. The PAC-1 antibody is conjugated with the fluorescent dye PE, allowing for easy detection and analysis of the target proteins.
Title: Structure of Anti-Human CD41/ITGA2B & CD61/ITGB3 Antibody (PAC-1), PE
The PAC-1 antibody is a mouse monoclonal antibody that specifically binds to the activated form of CD41/ITGA2B and CD61/ITGB3. The antibody is composed of two heavy chains and two light chains, with a molecular weight of approximately 150 kDa. The antibody has a high affinity for its target proteins, making it a valuable tool for studying platelet function.
Title: Activity of Anti-Human CD41/ITGA2B & CD61/ITGB3 Antibody (PAC-1), PE
The PAC-1 antibody is commonly used in flow cytometry and immunofluorescence assays to detect and quantify the expression of CD41/ITGA2B and CD61/ITGB3 on the surface of platelets. It is also used in functional studies to investigate the role of these integrin subunits in platelet activation and aggregation. The antibody has been shown to inhibit platelet aggregation induced by various agonists, providing further evidence of its specificity and activity.
Title: Applications of Anti-Human CD41/ITGA2B & CD61/ITGB3 Antibody (PAC-1), PE
The PAC-1 antibody has a wide range of applications in both basic and clinical research. It is commonly used to study platelet function and activation in various disease states, such as thrombosis, inflammation, and cancer. The antibody has also been used in studies investigating the role of integrins in cell adhesion, migration, and signaling. In addition, the PAC-1 antibody has potential diagnostic and therapeutic applications, as it can be used to identify and target activated platelets in various diseases.
Title: Research Target: CD41/ITGA2B and CD61/ITGB3
CD41/ITGA2B and CD61/ITGB3 are two closely related integrin subunits that form the αIIbβ3 heterodimer, also known as the platelet glycoprotein IIb/IIIa complex. These integrins are primarily expressed on the surface of platelets, where they play a crucial role in platelet adhesion, aggregation, and thrombus formation. Dysregulation of these integrins has been implicated in various diseases, including cardiovascular diseases, autoimmune disorders, and cancer.
Title: Role of CD41/ITGA2B and CD61/ITGB3 in Platelet Function
CD41/ITGA2B and CD61/ITGB3 are essential for platelet function and hemostasis. Upon platelet activation, these integrins undergo a conformational change, allowing them to bind to fibrinogen and other ligands, leading to platelet aggregation. This process is crucial for the formation of a stable platelet plug at the site of injury. In addition, CD41/ITGA2B and CD61/ITGB3 play a role in platelet signaling, regulating various cellular processes such as secretion, adhesion, and spreading.
Title: Implications of Dysregulated CD41/ITGA2B and CD61/ITGB3 in Disease
Dysregulation of CD41/ITGA2B and CD61/ITGB3 has been linked to various diseases. For example, mutations in these integrins have been associated with Glanz
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