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100ug
ProteoGenix
Recombinant Proteins
Escherichia coli (E. coli)
Elisa, WB
Duchenne muscular dystrophy (DMD) is a genetic disorder that affects the muscles, leading to progressive muscle weakness and loss of function. It is caused by mutations in the dystrophin gene, which results in the absence of the dystrophin protein. Dystrophin is an essential protein for maintaining the structural integrity of muscle cells. Without it, the muscles become weak and eventually degenerate, leading to the symptoms of DMD.
In recent years, researchers have developed a recombinant form of dystrophin, known as DMD recombinant protein. This protein is produced through genetic engineering techniques and is designed to mimic the structure and function of the natural dystrophin protein. DMD recombinant protein has shown promising results in preclinical studies and is currently being investigated as a potential treatment for DMD.
DMD recombinant protein is a large protein consisting of 3,685 amino acids. It shares a similar structure to the natural dystrophin protein, with four main domains: the N-terminal domain, the central rod domain, the cysteine-rich domain, and the C-terminal domain. The N-terminal domain is responsible for binding to other proteins in the muscle cell, while the central rod domain provides structural stability. The cysteine-rich domain is involved in the formation of disulfide bonds, which are essential for the proper folding of the protein. The C-terminal domain is responsible for anchoring the protein to the cell membrane.
The main function of DMD recombinant protein is to restore the structural integrity of muscle cells in individuals with DMD. It does this by binding to other proteins in the muscle cell, forming a complex that helps to maintain the structural stability of the cell membrane. This prevents the muscle cells from degenerating and helps to improve muscle function.
In addition to its structural role, DMD recombinant protein also has a signaling function. It has been shown to activate a signaling pathway called the AKT/mTOR pathway, which is involved in muscle growth and repair. This signaling activity of DMD recombinant protein may also contribute to its therapeutic effects in DMD.
DMD recombinant protein is currently being investigated as a potential treatment for DMD. It is administered through intravenous infusion and has shown promising results in preclinical studies. In a mouse model of DMD, treatment with DMD recombinant protein resulted in improved muscle function, increased muscle mass, and decreased muscle degeneration.
Several clinical trials are currently underway to evaluate the safety and efficacy of DMD recombinant protein in humans. These studies are primarily focused on assessing the protein’s ability to improve muscle function and delay disease progression in individuals with DMD.
DMD recombinant protein is a promising new treatment for DMD. Its structure and function closely resemble that of the natural dystrophin protein, making it a potential replacement therapy. By restoring the structural integrity of muscle cells and activating signaling pathways involved in muscle growth and repair, DMD recombinant protein has the potential to improve muscle function and delay disease progression in individuals with DMD. Ongoing clinical trials will provide more insight into its therapeutic potential and may lead to the approval of this protein as a drug target for DMD.
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