Recombinant Human TFG Protein, N-His-SUMO

Description of Recombinant Human TFG Protein, N-His-SUMO

Introduction to Recombinant Human TFG Protein

Recombinant Human TFG Protein, also known as Transforming Growth Factor Gamma, is a protein that plays a crucial role in cell growth, differentiation, and immune response. It is a member of the transforming growth factor superfamily and is encoded by the TGF gene. This protein is produced through recombinant DNA technology, making it highly pure and biologically active. Recombinant Human TFG Protein has various applications in the fields of medicine, biotechnology, and research. In this article, we will delve into the structure, activity, and applications of this important protein.

Structure of Recombinant Human TFG Protein

Recombinant Human TFG Protein is a homodimeric glycoprotein consisting of two identical subunits, each containing 112 amino acids. The molecular weight of this protein is approximately 25 kDa. The primary structure of Recombinant Human TFG Protein is similar to other members of the transforming growth factor superfamily, with a conserved cysteine knot motif. This motif is responsible for the formation of three intramolecular disulfide bonds, which give the protein its characteristic structure.

The three-dimensional structure of Recombinant Human TFG Protein has been determined through X-ray crystallography. It forms a compact, globular structure with a central hydrophobic core and an exposed hydrophilic surface. The two subunits of the protein are held together by non-covalent interactions, giving it a stable and rigid structure.

Activity of Recombinant Human TFG Protein

Recombinant Human TFG Protein is a multifunctional cytokine that exerts its effects through binding to specific cell surface receptors. It has been shown to have both pro-inflammatory and anti-inflammatory activities, depending on the context of the immune response. This protein is involved in the regulation of cell proliferation, differentiation, and apoptosis, making it a key player in tissue development and repair.

One of the major functions of Recombinant Human TFG Protein is its ability to activate and regulate the immune system. It acts as a chemoattractant for immune cells, such as monocytes, macrophages, and T cells, and stimulates their proliferation and differentiation. This protein also plays a role in the activation of B cells and the production of antibodies. In addition, Recombinant Human TFG Protein has been shown to have anti-tumor effects by inhibiting the growth of certain cancer cells.

Applications of Recombinant Human TFG Protein

Recombinant Human TFG Protein has a wide range of applications in the fields of medicine, biotechnology, and research. Its ability to regulate the immune response makes it a promising therapeutic target for various diseases, including autoimmune disorders, infectious diseases, and cancer. Recombinant Human TFG Protein has also been used in clinical trials for the treatment of chronic inflammatory diseases, such as rheumatoid arthritis and Crohn’s disease.

In the biotechnology industry, Recombinant Human TFG Protein is used in the production of monoclonal antibodies and other biopharmaceuticals. It is also used in cell culture media to enhance cell growth and protein production. In research, this protein is a valuable tool for studying the mechanisms of immune response and for developing new treatments for immune-related diseases.

Conclusion

Recombinant Human TFG Protein is a crucial protein that plays a significant role in cell growth, differentiation, and immune response. Its structure and activity have been extensively studied, and it has been shown to have a wide range of applications in medicine, biotechnology, and research. With ongoing research and advancements in recombinant DNA technology, Recombinant Human TFG Protein is poised to have an even greater impact in the future.