Recombinant Human ITPKA Protein, N-His

Description of Recombinant Human ITPKA Protein, N-His

Title: Understanding the Structure and Function of Recombinant Human ITPKA Protein

Introduction:
Recombinant proteins have revolutionized the field of biotechnology and have become essential tools in various scientific research and applications. One such protein is the Recombinant Human ITPKA Protein, which plays a crucial role in cellular signaling and metabolism. In this article, we will explore the structure, activity, and applications of this important protein.

Structure of Recombinant Human ITPKA Protein:
The Recombinant Human ITPKA Protein is a 70 kDa protein that belongs to the family of inositol 1,4,5-trisphosphate 3-kinases (ITPKs). It consists of 626 amino acids and is encoded by the ITPKA gene located on chromosome 15 in humans. The protein has a conserved catalytic domain and a regulatory domain, which are essential for its activity.

Activity of Recombinant Human ITPKA Protein:
The primary function of Recombinant Human ITPKA Protein is to catalyze the phosphorylation of inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4). This reaction is crucial for the regulation of intracellular calcium levels, which play a vital role in various cellular processes such as cell growth, differentiation, and apoptosis. The activity of Recombinant Human ITPKA Protein is tightly regulated by various factors, including calcium ions, ATP, and other signaling molecules.

Applications of Recombinant Human ITPKA Protein:
Recombinant Human ITPKA Protein has a wide range of applications in both basic research and industrial settings. Some of the key applications are listed below:

1. Studying cellular signaling pathways: The ability of Recombinant Human ITPKA Protein to regulate intracellular calcium levels makes it an essential tool for studying various cellular signaling pathways. It is commonly used in studies related to cancer, neurodegenerative diseases, and metabolic disorders.

2. Drug discovery: Dysregulation of calcium signaling is associated with various diseases, making Recombinant Human ITPKA Protein an attractive target for drug discovery. Its activity can be modulated by small molecules, making it a potential target for the development of novel therapeutics.

3. Production of recombinant antibodies: Recombinant Human ITPKA Protein has been used as an antigen to produce highly specific antibodies for various research and diagnostic purposes. These antibodies can be used to detect the expression and localization of the protein in different tissues and cell types.

4. Biopharmaceutical production: Recombinant proteins, including Recombinant Human ITPKA Protein, are widely used in the production of biopharmaceuticals. They are used as antigens, adjuvants, and carriers in the development of vaccines and other therapeutic proteins.

5. Agriculture: Recombinant Human ITPKA Protein has also been used in the field of agriculture to improve crop yield and stress tolerance. It has been shown to play a role in plant growth and development, making it a potential target for genetic engineering of crops.

Conclusion:
Recombinant Human ITPKA Protein is a vital protein that plays a crucial role in regulating intracellular calcium levels. Its structure and activity make it an essential tool for studying cellular signaling pathways and developing novel therapeutics. With its diverse applications in various fields, Recombinant Human ITPKA Protein continues to be a valuable protein in the scientific community.