4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand
ProteoGenix
Host species
Mammalian cells
Fragment Type
Ala27-Arg191
Protein Accession
P15692
Reference
PX-P5977
Note
For research use only
Description of VEGFA / VEGF165, C-His, recombinant protein
General information on VEGFA / VEGF165, C-His, recombinant protein
Structure
VEGF165 is a member of the VEGF (vascular endothelial growth factor) family of proteins, which are composed of four structural domains: an N-terminal signal peptide, a pro-region, a VEGF homology domain and a C-terminal core domain. The VEGF165 protein is a 165-amino acid glycoprotein, which is secreted and binds to the extracellular matrix.
Activity
VEGF165 is a transcription factor that acts as a growth factor for endothelial cells, stimulating their proliferation and migration. It also regulates the formation of new blood vessels, or angiogenesis. Additionally, VEGF165 has been found to modulate the expression of other genes involved in angiogenesis, such as matrix metalloproteinases.
Application
VEGF165 has a wide range of applications, including cancer therapy. It has been used as an antibody-drug target, as well as a therapeutic agent for the treatment of various types of cancer. Additionally, VEGF165 has been used to treat cardiovascular diseases, such as coronary artery disease, and has been investigated as a potential therapeutic agent for diabetic retinopathy.
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