Recombinant Human PPM1A, N-His

Description of Recombinant Human PPM1A, N-His

Introduction

Recombinant Human PPM1A, N-His is a protein that has gained significant attention in the field of drug discovery and development. It is a member of the protein phosphatase family and plays a crucial role in regulating various cellular processes. In this article, we will delve into the structure, activity and potential applications of this protein as a drug target.

Structure of Recombinant Human PPM1A, N-His

Recombinant Human PPM1A, N-His is a 63 kDa protein consisting of 576 amino acids. It contains a conserved protein phosphatase domain and a C-terminal domain that is unique to the PPM family. The protein also has a histidine tag at the N-terminus, which allows for easy purification and detection.

Activity of this protein

Recombinant Human PPM1A, N-His is a serine/threonine protein phosphatase that acts on a variety of substrates. It is primarily involved in the dephosphorylation of proteins involved in cell cycle regulation, DNA damage response, and stress signaling pathways. The protein has been shown to dephosphorylate key proteins such as p53, Chk1, and H2AX, thereby regulating their activity and cellular function.

Potential Applications as a Drug Target

The activity of Recombinant Human PPM1A, N-His in regulating various cellular processes makes it a promising drug target for a wide range of diseases. Here are some potential applications of this protein as a drug target:

Cancer

Aberrant cell cycle regulation and DNA damage response are key features of cancer cells. As Recombinant Human PPM1A, N-His plays a crucial role in these processes, it has been identified as a potential target for cancer therapy. Inhibition of this protein could lead to cell cycle arrest and sensitization of cancer cells to chemotherapeutic agents.

Neurodegenerative Diseases

Studies have shown that Recombinant Human PPM1A, N-His is involved in the regulation of neuronal survival and death. Dysregulation of this protein has been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Targeting this protein could potentially prevent or delay the progression of these diseases.

Metabolic Disorders

Recombinant Human PPM1A, N-His has also been implicated in the regulation of glucose and lipid metabolism. Inhibition of this protein has been shown to improve insulin sensitivity and reduce fat accumulation in animal models of obesity and type 2 diabetes. This makes it a potential target for the treatment of metabolic disorders.

Inflammatory Diseases

The activity of Recombinant Human PPM1A, N-His in regulating stress signaling pathways also makes it a potential target for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Inhibition of this protein could potentially reduce inflammation and alleviate symptoms of these diseases.

Conclusion

In summary, Recombinant Human PPM1A, N-His is a multifunctional protein with a diverse range of activities. Its role in regulating key cellular processes makes it a promising drug target for various diseases. Further research and development in this area could lead to the development of novel therapies for a wide range of disorders.