Recombinant Mouse CD115/CSF1R Protein, N-His

Description of Recombinant Mouse CD115/CSF1R Protein, N-His

Introduction

Recombinant Mouse CD115/CSF1R Protein is a protein that plays a crucial role in the immune system. It is a type I transmembrane protein that is expressed on the surface of various immune cells, including macrophages, monocytes, and dendritic cells. This protein is also known as Colony-Stimulating Factor 1 Receptor (CSF1R) and is encoded by the Csf1r gene in mice. In this article, we will discuss the structure, activity, and applications of Recombinant Mouse CD115/CSF1R Protein.

Structure of Recombinant Mouse CD115/CSF1R Protein

Recombinant Mouse CD115/CSF1R Protein is a 972 amino acid protein with a molecular weight of approximately 110 kDa. It consists of five domains: an extracellular domain, a transmembrane domain, a juxtamembrane domain, a kinase domain, and a C-terminal tail. The extracellular domain is responsible for ligand binding, while the kinase domain is involved in signal transduction.

The extracellular domain of Recombinant Mouse CD115/CSF1R Protein contains three immunoglobulin-like domains, which are important for receptor dimerization and ligand binding. The transmembrane domain is a hydrophobic region that anchors the protein to the cell membrane. The juxtamembrane domain is a short region that connects the transmembrane domain to the kinase domain and plays a role in regulating receptor activity.

The kinase domain of Recombinant Mouse CD115/CSF1R Protein is responsible for initiating downstream signaling cascades upon ligand binding. It contains all the necessary elements for kinase activity, including ATP- and substrate-binding sites. The C-terminal tail of the protein is involved in receptor internalization and degradation.

Activity of Recombinant Mouse CD115/CSF1R Protein

Recombinant Mouse CD115/CSF1R Protein is the receptor for Colony-Stimulating Factor 1 (CSF-1), a cytokine that regulates the growth, differentiation, and survival of myeloid cells. Upon binding of CSF-1, Recombinant Mouse CD115/CSF1R Protein undergoes dimerization and autophosphorylation, leading to the activation of downstream signaling pathways.

The major downstream signaling pathways activated by Recombinant Mouse CD115/CSF1R Protein include the MAPK/ERK, PI3K/Akt, and JAK/STAT pathways. These pathways play important roles in cell proliferation, survival, and differentiation. Recombinant Mouse CD115/CSF1R Protein also regulates the expression of various genes involved in immune response, inflammation, and tissue repair.

Applications of Recombinant Mouse CD115/CSF1R Protein

Recombinant Mouse CD115/CSF1R Protein has a wide range of applications in both basic research and clinical settings. Here are some of the key applications of this protein:

1. Studying immune cell development and function

Recombinant Mouse CD115/CSF1R Protein is essential for the development and function of immune cells, particularly macrophages and monocytes. Therefore, it is commonly used in studies to understand the role of these cells in various diseases and immune responses.

2. Investigating the role of CSF-1 signaling in cancer

Aberrant activation of CSF-1 signaling has been linked to the development and progression of various cancers. Recombinant Mouse CD115/CSF1R Protein is often used to study the role of this signaling pathway in cancer and to develop potential therapeutic strategies targeting this pathway.

3. Developing immunotherapies

Recombinant Mouse CD115/CSF1R Protein has been used in the development of immunotherapies targeting immune cells, such as macrophages and dendritic cells. These therapies aim to boost the