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Developing antibodies against cancer targets? Discover the world’s first Human Cancer Phage Display Library
Unlock the full potential of native-like antibodies with ProteoGenix’s Custom Single B Cell Sequencing Service. With the RocketAb immunization protocol, revolutionize your mAb development by offering a fast turnaround—saving up to 4 weeks compared to traditional methods and using 50% less antigen. Choose from mouse and rabbit species to best suit your project needs, all while ensuring maximum B cell diversity and the preservation of natural VL/VH pairing. Our innovative adjuvant promotes native protein recognition without the need for emulsification, setting a new benchmark for efficiency and specificity in single B cell cloning services. Guaranteeing at least three unique, high-affinity (10^-12m) clones, ProteoGenix accelerates your path to breakthrough discoveries with high-quality, high-affinity monoclonal antibodies. Opt for ProteoGenix and transform your antibody development challenges into pioneering solutions with our leading-edge custom B cell sorting services.
An ideal example of the insights you can expect from this type of report
This comprehensive report includes:
Download the Data Report – protein antigen
Download the Data Report – peptide antigen
Fast Turnaround
Save up to 4 weeks with our RocketAb protocol.
Less Antigen Required
Use 50% less antigen for immunizations.
Choice of Species
Mouse and rabbit options for mAb development.
Native Antigen Recognition
Our adjuvant ensures no emulsification needed.
High-Affinity Clones Guaranteed
Receive at least 3 clones with 10^-12 M affinity
Advanced B Cell Sorting
Utilizing FACS for precise antigen-specific isolation.
Proprietary High-Performance Cells
For efficient antibody gene expression.
IP-Free Guarantee
Full ownership of your research outcomes.
High Throughput Screening
Expedite discovery with our advanced platforms.
Immunization: 4-6 weeks
Single B-cell Sorting and Screening: 2-3 weeks
Recombinant Mouse & Rabbit Antibody Production and Screening: 2 weeks
ProteoGenix’s B cell sorting services offer a flexible and customizable pricing structure to cater to your individual needs. Our prices start at a few thousand euros with pricing depending on the number of specific requirements for each project. The pricing is largely influenced by the number of antibody sequences to be analyzed and the scope of the service purchased.
We also offer the option for customers to enhance their single B cell sorting experience with supplementary services. These additional services include ELISA for positive/negative screening against specific peptides, proteins, or small molecules, as well as cross-reactivity profiling. Furthermore, our Competitive ELISA service enables the identification of clones with blocking or neutralizing activity, providing invaluable insights for therapeutic development.
Building a custom antibody using B cell isolation is a valuable investment that yields long-term cost savings. By precisely selecting high-affinity antibody clones early in the development process, it minimizes resources spent on less promising candidates. The targeted approach reduces downstream costs, ensuring efficient large-scale production and accelerating the path to a successful therapeutic, resulting in substantial savings in the long run.
At ProteoGenix, we understand the uniqueness of each project and aim to provide tailored solutions for our clients. Our team of experts works closely with customers to evaluate their specific needs and propose the most appropriate services within their budget. With our transparent and ranking-based pricing approach, customers can confidently choose the services that best align with their research objectives, ultimately ensuring the success of their single B cell sorting projects.
At ProteoGenix, our single B cell antibody technologies are designed for rapid and efficient results. The customer can get his antibody within only 6 weeks, ensuring a quick turnaround for their project.
We are proud to introduce our new immunization protocol that offers significant time savings, allowing us to complete the process 50% faster than our competitors. Immunization delays have been reduced from the typical 6-8 weeks to just 4-6 weeks, further streamlining the B cell sorting timeline and providing customers with even faster access to their desired antibody sequences.
You can patent your antibody sequence that is delivered from our B cell sorting service. We believe in providing our customers with full ownership of their antibody sequences, giving you the freedom and protection to secure intellectual property rights for your valuable discoveries.
With our B cell sorting services, you can confidently pursue patent applications and protect the innovative potential of your custom antibodies, ensuring their exclusivity and commercial value in the market.
Traditional monoclonal antibody technology involves creating a hybrid cell line by fusing B-cells from immunized mice with an immortal B-cell myeloma cell line. The resulting fused cells are referred to as hybridoma cells because they are a hybrid between a healthy B-cell and a transformed B-cell. Hybridoma cells are isolated and separated into individual wells to assess the antigen-binding potential of the secreted antibodies. The process of B-cell fusion is inefficient. Many B-cells are lost during this process, decreasing the probability of discovering a rare antibody that binds difficult-to-target epitopes. In contrast, our single B-cell screening method maximizes the B-cell isolation and characterization of antibodies secreted from B-cells increasing the probability of discovering rare antibodies that bind a target antigen with precision.
Picking the right team of antibody experts to isolate single B-cells for monoclonal antibody production is critically important given the numerous challenges involved in B-cell isolation. First, the ability to make custom antigens, including conformation-dependent antigens, is critical to success. These antigens are not only necessary for the immunization steps but also for the isolation of antigen-specific B-cells by FACS. The synthesized antigen must be a specific purity and concentration for optimal success. Successful B-cell isolation also requires an array of properly calibrated precision instruments to isolate B-cells and verify antigen binding capacity. In addition, the ability to culture naive and memory B-cells requires well-optimized conditions to promote cell proliferation and maintain cell viability. These parameters alone require years of optimization and expertise. At ProteoGenix, our antibody experts have an average of 25 years of experience in antigen synthesis and antibody development. With 3 therapeutic antibodies on the market and over 30 antibodies in the preclinical and clinical phases of investigation, we know how to make high-performing antibodies for our clients. Book a call with one of our antibody experts to learn how we can help you accelerate your project needs.
Traditional monoclonal antibody development methods, such as hybridoma technology, have been instrumental in advancing biomedicine, offering a solid foundation for producing a wide array of therapeutic antibodies. These methods have enabled significant discoveries and developments in the field. Complementing this, ProteoGenix’s single B cell sequencing service introduces a contemporary approach that further enhances the precision and efficiency of antibody discovery. Below is a table comparing the three methods used for monoclonal antibody development.
One of the key benefits of single B cell sequencing is its ability to preserve the natural pairing of heavy and light chains of antibodies. This preservation is crucial for maintaining the native function and specificity of antibodies, which is often compromised in traditional methods. Our custom single B cell screening and single B cell cloning services are designed to leverage this advantage, providing researchers with high-fidelity antibodies for their projects.
Hybridoma development Services – ProteoGenix Recombinant Antibody Services – ProteoGenix Phage Display Custom Services – Proteogenix
Monoclonal Antibody Humanization Services
Antibody Affinity Maturation Solutions
ADC Development Services
Bispecific Antibody Services
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