CD274 / PD-L1 / B7-H1, C-His, recombinant protein

General information on CD274 / PD-L1 / B7-H1, C-His, recombinant protein

CD274 / PD-L1 / B7-H1 Structure

CD274, also known as PD-L1 or B7-H1, is a type I transmembrane glycoprotein that is expressed on the surface of various cell types, including T cells, B cells, macrophages, dendritic cells, and some tumor cells. The extracellular domain of CD274 is composed of three immunoglobulin-like domains, while the intracellular domain contains a cytoplasmic tail that is important for the regulation of its activity.

CD274 / PD-L1 / B7-H1 Activity

CD274 acts as an inhibitory receptor that binds to its ligand, programmed death ligand 1 (PD-L1). This interaction between CD274 and PD-L1 results in the inhibition of T cell activation and proliferation, as well as the induction of anergy and apoptosis in T cells. In addition, CD274 can also bind to other ligands, including B7 family members, which can lead to the activation of T cells.

CD274 / PD-L1 / B7-H1 Application

CD274 has been studied extensively in the context of cancer immunotherapy, as it is often overexpressed on tumor cells.