Recombinant Human GDI2 Protein, N-His

Description of Recombinant Human GDI2 Protein, N-His

Introduction to Recombinant Human GDI2 Protein

Recombinant Human GDI2 Protein, also known as GDP dissociation inhibitor 2, is a protein that plays a crucial role in regulating the activity of small GTPases. This protein is encoded by the GDI2 gene and is involved in various cellular processes such as cell migration, cytoskeletal organization, and intracellular signaling. In this article, we will discuss the structure, activity, and applications of Recombinant Human GDI2 Protein.

Structure of Recombinant Human GDI2 Protein

Recombinant Human GDI2 Protein is composed of 443 amino acids and has a molecular weight of approximately 48 kDa. It consists of three distinct domains: an N-terminal regulatory domain, a central catalytic domain, and a C-terminal lipid-binding domain. The N-terminal domain is responsible for the binding of small GTPases, while the catalytic domain is involved in the dissociation of GDP from the GTPases. The lipid-binding domain is responsible for the interaction of GDI2 with cellular membranes.

Activity of Recombinant Human GDI2 Protein

The main function of Recombinant Human GDI2 Protein is to regulate the activity of small GTPases, which are essential for various cellular processes. These GTPases act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. GDI2 binds to the GDP-bound form of small GTPases and prevents them from being activated, thereby regulating their activity. This protein also plays a role in the transport of GTPases between cellular compartments.

Apart from its role in regulating GTPases, Recombinant Human GDI2 Protein has been shown to have other activities as well. It has been reported to interact with actin and microtubules, suggesting a potential role in regulating the cytoskeleton. It has also been shown to interact with various signaling proteins, indicating its involvement in intracellular signaling pathways.

Applications of Recombinant Human GDI2 Protein

Recombinant Human GDI2 Protein has been widely used in various research studies to understand its role in cellular processes. It has also been explored as a potential therapeutic target for various diseases. For instance, GDI2 has been found to be upregulated in certain types of cancer, and targeting this protein may have therapeutic benefits. Additionally, GDI2 has been shown to play a role in neuronal development and function, making it a potential target for neurological disorders.

Moreover, Recombinant Human GDI2 Protein has been used in the development of diagnostic assays and vaccines. It has been reported to act as an antigen in the immune response against certain types of cancer, making it a potential biomarker for cancer diagnosis and a target for cancer vaccines.

In summary, Recombinant Human GDI2 Protein is a crucial regulator of small GTPases and plays a role in various cellular processes. Its structure, activity, and potential applications make it a valuable protein for research and therapeutic purposes. Further studies on this protein may provide a better understanding of its functions and potential as a therapeutic target.