Recombinant Human IFNGR2 Protein, N-His

Description of Recombinant Human IFNGR2 Protein, N-His

Introduction to Recombinant Human IFNGR2 Protein

Recombinant Human IFNGR2 Protein, also known as Interferon Gamma Receptor 2, is a type II transmembrane protein that plays a crucial role in the immune system. It is a member of the cytokine receptor family and is involved in the signaling pathway of interferon-gamma (IFN-γ), a key regulator of immune responses.

Structure of Recombinant Human IFNGR2 Protein

The gene for IFNGR2 is located on chromosome 21 and encodes a protein of 337 amino acids with a molecular weight of approximately 38 kDa. The protein consists of a single extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain contains two fibronectin type III domains, which are involved in ligand binding. The transmembrane domain anchors the protein to the cell membrane, while the cytoplasmic domain is responsible for signal transduction.

Recombinant Human IFNGR2 Protein is produced in a laboratory using recombinant DNA technology. The gene for IFNGR2 is inserted into a suitable expression vector and transfected into host cells, such as E. coli or mammalian cells. The host cells then produce large quantities of the protein, which can be purified and used for various applications.

Activity of Recombinant Human IFNGR2 Protein

Recombinant Human IFNGR2 Protein is a high-affinity receptor for IFN-γ, which is a cytokine produced by activated T cells and natural killer (NK) cells. IFN-γ plays a crucial role in the immune response against viral and bacterial infections, as well as in the control of tumor growth. The binding of IFN-γ to IFNGR2 triggers a signaling cascade that leads to the activation of various immune cells, including macrophages and dendritic cells.

IFNGR2 also plays a role in regulating the production of other cytokines, such as interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF-α), which are important mediators of the immune response. This makes IFNGR2 an essential component of the immune system and a potential target for therapeutic interventions.

Applications of Recombinant Human IFNGR2 Protein

Recombinant Human IFNGR2 Protein has a wide range of applications in both research and clinical settings. It is commonly used as an antigen in immunological studies to investigate the role of IFNGR2 in immune responses. It can also be used to study the interactions between IFN-γ and its receptor and to identify potential therapeutic targets for immune-related diseases.

In addition, Recombinant Human IFNGR2 Protein has potential therapeutic applications. It has been shown to enhance the antitumor activity of IFN-γ in preclinical studies, making it a promising candidate for cancer immunotherapy. It has also been investigated as a potential treatment for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, as well as for chronic viral infections, such as hepatitis B and C.

Furthermore, Recombinant Human IFNGR2 Protein can be used for the development of diagnostic tools, such as ELISA kits, for the detection of IFN-γ and its receptor in biological samples. This can aid in the diagnosis and monitoring of various diseases.

Conclusion

Recombinant Human IFNGR2 Protein is a crucial component of the immune system and plays a vital role in immune responses. Its structure, activity, and various applications make it a valuable tool for both basic research and clinical applications. Further studies on IFNGR2 and its interactions with IFN-γ may lead to the development of new treatments for immune-related diseases and cancer.