Recombinant Human RHD Protein, N-His-SUMO

Description of Recombinant Human RHD Protein, N-His-SUMO

Introduction to Recombinant Human RHD Protein

Recombinant Human RHD Protein, also known as RH D antigen, is a protein that is encoded by the RHD gene located on chromosome 1. This protein is a key component of the Rh blood group system and is responsible for the production of the Rh D antigen on the surface of red blood cells. The Rh D antigen is a major antigen in the Rh blood group system and plays a critical role in blood transfusions and pregnancy. In this article, we will explore the structure, activity, and applications of Recombinant Human RHD Protein.

Structure of Recombinant Human RHD Protein

Recombinant Human RHD Protein is a glycoprotein composed of 417 amino acids with a molecular weight of approximately 45 kDa. It is a transmembrane protein with a single transmembrane domain and a large extracellular domain. The extracellular domain contains 10 potential N-glycosylation sites, which are important for the proper folding and stability of the protein. The RHD protein also has a highly conserved cytoplasmic domain, which is responsible for its intracellular signaling functions.

Activity of Recombinant Human RHD Protein

The main function of Recombinant Human RHD Protein is to act as an antigen and stimulate the production of antibodies in response to the presence of the Rh D antigen on red blood cells. This antigen-antibody response is important for blood transfusions and pregnancy. In blood transfusions, the presence of Rh D antigen on the red blood cells of the donor can trigger an immune response in the recipient, leading to a potentially life-threatening condition known as hemolytic disease of the newborn. Similarly, during pregnancy, if a mother is Rh D negative and the fetus is Rh D positive, the mother’s immune system can produce antibodies against the Rh D antigen, which can cross the placenta and harm the fetus. Recombinant Human RHD Protein is also involved in the regulation of cell adhesion, migration, and invasion, making it an important protein in various physiological and pathological processes.

Applications of Recombinant Human RHD Protein

Recombinant Human RHD Protein has a wide range of applications in the fields of medicine and biotechnology. Its most significant application is in the production of Rh D immune globulin, a medication used to prevent hemolytic disease of the newborn in Rh D negative mothers. Rh D immune globulin is produced by purifying the antibodies against the Rh D antigen from the plasma of individuals who have been immunized with Recombinant Human RHD Protein. This medication has greatly reduced the incidence of hemolytic disease of the newborn and has saved countless lives.

In addition to its role in medicine, Recombinant Human RHD Protein is also used in research and development of new therapies for various diseases. It has been studied for its potential in cancer treatment, as it is involved in cell adhesion and migration, which are important processes in cancer metastasis. It has also shown promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, where it may play a role in regulating the immune response.

Furthermore, Recombinant Human RHD Protein has been used as a tool in biotechnology for the production of other recombinant proteins. It has been genetically modified to express various proteins on its surface, making it a useful tool for protein purification and isolation.

Conclusion

In conclusion, Recombinant Human RHD Protein is a crucial protein in the Rh blood group system, with important roles in blood transfusions, pregnancy, and various physiological and pathological processes. Its structure, activity, and applications make it a valuable protein in medicine and biotechnology. Further research on this protein may lead to the development of new therapies and treatments for various diseases.