Recombinant Human SDF2L1, N-His

Description of Recombinant Human SDF2L1, N-His

Introduction to Recombinant Human SDF2L1

Recombinant Human SDF2L1, also known as Stromal Cell-Derived Factor 2-Like 1, is a protein that is encoded by the SDF2L1 gene in humans. It belongs to the SDF2 family of proteins and is involved in various cellular processes such as protein folding, endoplasmic reticulum (ER) stress response, and immune response. In this article, we will discuss the structure, activity, and application of Recombinant Human SDF2L1.

Structure of Recombinant Human SDF2L1

Recombinant Human SDF2L1 is a 17 kDa protein that contains 152 amino acids. It is composed of a signal peptide, a propeptide, and a mature protein. The signal peptide is responsible for the secretion of the protein from the cell, while the propeptide is cleaved off to form the mature protein. The mature protein consists of a single domain with a conserved cysteine-rich region. This region is essential for the proper folding and stability of the protein.

Activity of Recombinant Human SDF2L1

The primary function of Recombinant Human SDF2L1 is to assist in protein folding in the ER. It is a chaperone protein that helps in the correct folding of newly synthesized proteins, preventing their aggregation and promoting their transport to the Golgi apparatus. It also plays a crucial role in the ER stress response, which is a cellular mechanism to cope with the accumulation of misfolded proteins in the ER. Recombinant Human SDF2L1 interacts with other ER chaperones, such as BiP and GRP94, to maintain the proper folding environment in the ER. Additionally, it has been shown to have a role in the immune response, as it can activate the NF-κB signaling pathway and induce the production of pro-inflammatory cytokines.

Application of Recombinant Human SDF2L1

Recombinant Human SDF2L1 has various applications in the fields of biotechnology and medicine. One of the main applications of this protein is in the production of recombinant proteins. As a chaperone protein, it can improve the yield and quality of recombinant proteins by aiding in their proper folding. This is particularly useful for the production of complex proteins, such as antibodies, hormones, and growth factors. Recombinant Human SDF2L1 can also be used in the production of therapeutic proteins, where proper folding is critical for their function.

In addition to its role in protein production, Recombinant Human SDF2L1 has potential applications in the treatment of diseases. Studies have shown that it can protect cells from ER stress-induced apoptosis, making it a potential therapeutic target for diseases associated with ER stress, such as neurodegenerative diseases and diabetes. It has also been reported to have anti-inflammatory properties, making it a potential candidate for the treatment of inflammatory diseases.

Conclusion

In summary, Recombinant Human SDF2L1 is a 17 kDa protein involved in protein folding, ER stress response, and immune response. Its structure consists of a signal peptide, a propeptide, and a mature protein with a conserved cysteine-rich region. Its main activity is to assist in protein folding and maintain the proper folding environment in the ER. It has various applications in the production of recombinant proteins and potential therapeutic applications in the treatment of diseases. Further research on Recombinant Human SDF2L1 may uncover more functions and potential applications of this protein in the future.