Recombinant Human SSR2 Protein, N-His

Description of Recombinant Human SSR2 Protein, N-His

Introduction to Recombinant Human SSR2 Protein

Recombinant Human SSR2 Protein, also known as Signal Sequence Receptor 2, is a protein that plays a crucial role in the process of protein synthesis in eukaryotic cells. This protein is encoded by the SSR2 gene and is a part of the signal recognition particle (SRP) complex, which is responsible for targeting proteins to the endoplasmic reticulum (ER) for proper folding and modification.

Structure of Recombinant Human SSR2 Protein

The Recombinant Human SSR2 Protein is composed of 181 amino acids and has a molecular weight of approximately 20 kDa. It is a transmembrane protein with a hydrophobic N-terminal signal sequence that is responsible for targeting the protein to the ER. The signal sequence is followed by a short cytoplasmic domain and a large luminal domain, which contains the conserved GTP-binding domain.

The luminal domain of Recombinant Human SSR2 Protein also contains three cysteine residues that are involved in disulfide bond formation, which is crucial for the proper folding of proteins in the ER. The transmembrane domain of this protein is composed of 20 hydrophobic amino acids that anchor it to the ER membrane.

Activity of Recombinant Human SSR2 Protein

The main function of Recombinant Human SSR2 Protein is to recognize and bind to the signal sequence of newly synthesized proteins, thus targeting them to the ER for further processing. This protein is a key component of the SRP complex, which also includes the SRP receptor and the SRP RNA. Together, these components form a complex that binds to the signal sequence of the protein and directs it to the ER membrane.

Once the protein reaches the ER, the SRP complex interacts with the SRP receptor, which then releases the protein into the translocation channel for further processing. During this process, Recombinant Human SSR2 Protein also plays a role in the proper folding and modification of the protein, ensuring its functionality.

Application of Recombinant Human SSR2 Protein

The use of Recombinant Human SSR2 Protein has several applications in the field of biotechnology and pharmaceutical research. This protein is commonly used in recombinant protein expression systems to improve the efficiency of protein production. By targeting the protein to the ER, Recombinant Human SSR2 Protein ensures proper folding and modification, leading to higher yields of functional proteins.

Moreover, Recombinant Human SSR2 Protein is also used in the study of protein targeting and translocation, as well as in understanding the process of protein folding in the ER. It is also a valuable tool in drug discovery and development, as it plays a crucial role in the proper folding of therapeutic proteins, ensuring their effectiveness.

Conclusion

In summary, Recombinant Human SSR2 Protein is a crucial component of the SRP complex that plays a vital role in protein synthesis and processing in eukaryotic cells. Its structure, activity and applications make it a valuable tool in various fields of research and biotechnology. The use of this protein has greatly improved the efficiency and success of recombinant protein production and has also contributed to a better understanding of protein targeting and folding in the ER.

Keywords: Recombinant Human SSR2 Protein, antigen, signal sequence receptor 2, protein synthesis, signal recognition particle, ER membrane, protein folding, protein modification, recombinant protein expression, drug discovery.