Recombinant Mouse CDH13 Protein, N-His

Description of Recombinant Mouse CDH13 Protein, N-His

Introduction

Recombinant Mouse CDH13 Protein, also known as Cadherin-13 or T-cadherin, is a cell adhesion molecule that plays a crucial role in various physiological processes, including cell-cell adhesion, cell migration, and signal transduction. This protein is encoded by the CDH13 gene and is a member of the cadherin superfamily. Recombinant Mouse CDH13 Protein is widely used in research and therapeutic applications due to its unique structure and diverse functions.

Structure of Recombinant Mouse CDH13 Protein

Recombinant Mouse CDH13 Protein is a transmembrane glycoprotein that consists of 718 amino acids and has a molecular weight of approximately 83 kDa. It is composed of five extracellular cadherin domains, a transmembrane domain, and a cytoplasmic domain. The extracellular domains are responsible for the adhesive properties of the protein, while the cytoplasmic domain interacts with intracellular signaling molecules.

The extracellular domains of Recombinant Mouse CDH13 Protein contain calcium-binding sites, which are essential for the protein’s adhesive function. These domains also have conserved amino acid sequences that are responsible for the homotypic and heterotypic interactions with other cadherin molecules.

The transmembrane domain of Recombinant Mouse CDH13 Protein anchors the protein to the cell membrane, while the cytoplasmic domain interacts with various signaling molecules, such as β-catenin, p120-catenin, and α-catenin. These interactions are crucial for the regulation of cell signaling pathways and the maintenance of cell-cell adhesion.

Activity of Recombinant Mouse CDH13 Protein

Recombinant Mouse CDH13 Protein is primarily involved in cell-cell adhesion and migration. It mediates homotypic and heterotypic interactions between cells, which are essential for the formation and maintenance of tissues and organs. The protein also regulates cell migration by modulating the activity of signaling pathways, such as the Rho GTPase pathway.

Moreover, Recombinant Mouse CDH13 Protein has been shown to have anti-angiogenic properties. It inhibits the formation of new blood vessels by binding to and sequestering vascular endothelial growth factor (VEGF). This activity is crucial in the development of therapeutic strategies for diseases that involve abnormal angiogenesis, such as cancer.

Application of Recombinant Mouse CDH13 Protein

Recombinant Mouse CDH13 Protein has a wide range of applications in both research and therapeutic settings. In research, the protein is used as an antigen for the production of specific antibodies to study its expression and function in different tissues and cell types. It is also used in cell adhesion assays to investigate its adhesive properties and interactions with other molecules.

In the therapeutic setting, Recombinant Mouse CDH13 Protein has potential applications in the treatment of various diseases. Its anti-angiogenic properties make it a promising candidate for the development of anti-cancer therapies. Additionally, the protein has been shown to play a role in the regulation of lipid metabolism and insulin signaling, making it a potential target for the treatment of metabolic disorders, such as obesity and type 2 diabetes.

Conclusion

Recombinant Mouse CDH13 Protein is a crucial cell adhesion molecule that plays diverse roles in physiological processes. Its unique structure, adhesive properties, and interactions with signaling molecules make it a valuable tool for research and a promising target for therapeutic interventions. With ongoing research and advancements in recombinant protein technology, the potential applications of Recombinant Mouse CDH13 Protein are continuously expanding, providing new insights into its functions and potential therapeutic benefits.