Recombinant Mouse IL23R Protein, N-His

Description of Recombinant Mouse IL23R Protein, N-His

Introduction

Recombinant Mouse IL23R Protein is a highly purified, bioactive protein produced through recombinant DNA technology. It is a member of the interleukin-23 receptor family and plays a crucial role in the immune response and inflammation. In this article, we will explore the structure, activity, and potential applications of this important protein.

Structure

The Recombinant Mouse IL23R Protein is a 629 amino acid protein with a predicted molecular mass of approximately 70 kDa. It consists of a single transmembrane domain and a cytoplasmic tail. The extracellular region of the protein contains a fibronectin type III domain and a cytokine receptor domain. The intracellular region contains a conserved Box1 motif, which is essential for signal transduction.

Activity

The main function of Recombinant Mouse IL23R Protein is to bind to the cytokine IL-23 and activate downstream signaling pathways. IL-23 is a heterodimeric cytokine composed of two subunits, p19 and p40. The p19 subunit binds to the IL23R protein, leading to the activation of the JAK-STAT signaling pathway. This results in the production of pro-inflammatory cytokines, such as IL-17, IL-22, and TNF-α, which play a crucial role in the immune response against pathogens and in the development of autoimmune diseases.

In addition to its role in the immune response, Recombinant Mouse IL23R Protein has been shown to play a role in the development of certain cancers. Studies have found that IL23R is overexpressed in various types of cancer, including breast, colon, and lung cancer. This suggests that IL23R may also play a role in promoting tumor growth and progression.

Applications

Research

Recombinant Mouse IL23R Protein is an essential tool in understanding the role of IL23R in the immune response and inflammation. It is commonly used in research studies to investigate the signaling pathways activated by IL-23 and to study the role of IL23R in various diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis.

Furthermore, Recombinant Mouse IL23R Protein is also used in studies to explore potential therapeutic targets for diseases associated with IL23R. By understanding the structure and function of this protein, researchers can develop targeted therapies to modulate its activity and potentially treat diseases such as cancer and autoimmune disorders.

Therapeutic Use

Recombinant Mouse IL23R Protein has potential therapeutic applications in the treatment of various diseases. As mentioned earlier, studies have shown that IL23R is overexpressed in certain cancers, making it a potential target for cancer therapy. By blocking the interaction between IL23R and IL-23, it may be possible to inhibit the growth and progression of these cancers.

In addition, IL23R has been implicated in the development of autoimmune diseases, such as Crohn’s disease and psoriasis. Recombinant Mouse IL23R Protein can be used as a therapeutic agent to block the activity of IL-23, thereby reducing inflammation and potentially treating these diseases.

Conclusion

In summary, Recombinant Mouse IL23R Protein is a crucial protein in the immune response and inflammation. Its structure and function have been extensively studied, and it has potential applications in both research and therapeutics. By understanding the role of IL23R, we can gain valuable insights into the development of diseases and potentially develop targeted treatments to improve human health.