Recombinant Mouse KIRREL1 Protein, N-His

Description of Recombinant Mouse KIRREL1 Protein, N-His

The Structure of Recombinant Mouse KIRREL1 Protein

Recombinant Mouse KIRREL1 Protein, also known as Kin of IRRE-like protein 1, is a transmembrane protein that belongs to the immunoglobulin superfamily. It is encoded by the KIRREL1 gene and is highly expressed in the central nervous system, particularly in the brain and spinal cord. The protein is composed of 455 amino acids and has a predicted molecular weight of 50 kDa.

The primary structure of Recombinant Mouse KIRREL1 Protein consists of a signal peptide at the N-terminus, followed by three immunoglobulin-like domains (Ig-like domains). The first two Ig-like domains are responsible for the homophilic binding of KIRREL1 to itself, while the third domain is involved in heterophilic interactions with other molecules. The C-terminus of the protein contains a conserved PDZ-binding motif, which allows it to interact with PDZ domain-containing proteins.

The tertiary structure of Recombinant Mouse KIRREL1 Protein is characterized by a horseshoe-shaped conformation, with the three Ig-like domains arranged in a linear fashion. The first two domains are connected by a flexible linker region, while the third domain is connected to the transmembrane domain by a short linker. The transmembrane domain is followed by a short cytoplasmic tail, which contains the PDZ-binding motif.

The Activity of Recombinant Mouse KIRREL1 Protein

Recombinant Mouse KIRREL1 Protein is primarily involved in cell adhesion and signaling processes. As a transmembrane protein, it is anchored to the cell membrane and can interact with other molecules on the surface of neighboring cells. The homophilic binding of KIRREL1 to itself promotes cell-cell adhesion, which is important for the development and maintenance of the central nervous system.

In addition to homophilic interactions, Recombinant Mouse KIRREL1 Protein can also interact with other molecules through its third Ig-like domain. This heterophilic binding allows the protein to participate in signaling pathways, particularly in the formation and maintenance of synapses in the brain. Studies have shown that KIRREL1 is essential for the proper development of neuronal connections and plays a crucial role in synaptic plasticity, which is important for learning and memory.

Furthermore, the PDZ-binding motif at the C-terminus of Recombinant Mouse KIRREL1 Protein enables it to interact with PDZ domain-containing proteins, which are involved in a variety of cellular processes. This interaction may play a role in the regulation of KIRREL1 activity and its localization within the cell.

The Application of Recombinant Mouse KIRREL1 Protein

Recombinant Mouse KIRREL1 Protein has been widely used as a research tool to study its role in cell adhesion and signaling. It has also been implicated in various diseases, making it a potential therapeutic target. For instance, mutations in the KIRREL1 gene have been associated with neurodevelopmental disorders such as autism and schizophrenia. Studies have also shown that KIRREL1 is involved in the progression of certain types of cancer, making it a potential target for cancer therapy.

Recombinant Mouse KIRREL1 Protein is commercially available for use in various research applications. It can be used in cell adhesion assays to study its homophilic and heterophilic binding properties. It can also be used in biochemical assays to investigate its interaction with PDZ domain-containing proteins. Furthermore, the protein can be used in animal models to study its role in neurodevelopment and synaptic plasticity.

In conclusion, Recombinant Mouse KIRREL1 Protein is a transmembrane protein with a unique structure and diverse functions. Its involvement in cell adhesion and signaling processes makes it a crucial player in the development and maintenance of the central nervous system. Its potential role in various diseases also highlights its importance as a therapeutic target. With its availability as a research tool, Recombinant Mouse KIRREL1 Protein continues to contribute to our understanding of the complex mechanisms