Recombinant Mouse SFRP4 Protein, N-His-SUMO

Description of Recombinant Mouse SFRP4 Protein, N-His-SUMO

Introduction to Recombinant Mouse SFRP4 Protein

Recombinant Mouse SFRP4 Protein is a type of recombinant protein that is widely used in scientific research and biotechnology applications. It is a member of the secreted frizzled-related protein (SFRP) family, which plays important roles in regulating cell growth, development, and differentiation. SFRP4 is a secreted glycoprotein that acts as an antagonist of the Wnt signaling pathway, which is involved in various cellular processes such as cell proliferation, differentiation, and migration. In this article, we will discuss the structure, activity, and application of Recombinant Mouse SFRP4 Protein.

Structure of Recombinant Mouse SFRP4 Protein

Recombinant Mouse SFRP4 Protein is a 346-amino acid protein with a molecular weight of approximately 38 kDa. It contains a signal peptide at the N-terminus, which is responsible for its secretion. The protein also has a cysteine-rich domain at the C-terminus, which is essential for its interaction with Wnt ligands. Recombinant Mouse SFRP4 Protein shares high sequence homology with other members of the SFRP family, particularly with SFRP1, SFRP2, and SFRP5. These proteins have similar structures and functions, but they show different tissue-specific expression patterns.

Activity of Recombinant Mouse SFRP4 Protein

Recombinant Mouse SFRP4 Protein acts as a competitive inhibitor of the Wnt signaling pathway. It binds to Wnt ligands and prevents their interaction with the Frizzled receptors, thereby inhibiting the activation of downstream signaling pathways. This activity of SFRP4 is important for maintaining the balance between cell proliferation and differentiation during embryonic development and tissue homeostasis. Dysregulation of the Wnt signaling pathway has been linked to various diseases, including cancer, making SFRP4 a potential therapeutic target.

In addition to its role in Wnt signaling, Recombinant Mouse SFRP4 Protein also has other activities. It has been shown to inhibit the activity of matrix metalloproteinases (MMPs), which are enzymes involved in extracellular matrix degradation. This activity of SFRP4 is important for regulating tissue remodeling and wound healing. Moreover, SFRP4 has been reported to have antiangiogenic properties, which may contribute to its role in tumor suppression.

Application of Recombinant Mouse SFRP4 Protein

Recombinant Mouse SFRP4 Protein has a wide range of applications in scientific research and biotechnology. It is commonly used as an antigen in immunoassays, such as ELISA and Western blot, for the detection and quantification of SFRP4 in biological samples. It can also be used as a control protein in experiments involving the Wnt signaling pathway, to confirm the specificity of the effects observed.

One of the major applications of Recombinant Mouse SFRP4 Protein is in cancer research. Due to its role as a Wnt signaling antagonist, SFRP4 has been studied as a potential tumor suppressor in various types of cancer, including breast, colon, and prostate cancer. Recombinant Mouse SFRP4 Protein has been used in preclinical studies to investigate its effects on cancer cell growth, migration, and invasion. It has also been tested as a potential therapeutic agent for cancer treatment, either alone or in combination with other drugs.

Furthermore, Recombinant Mouse SFRP4 Protein has been used in tissue engineering and regenerative medicine. Its ability to inhibit MMPs and promote wound healing makes it a promising candidate for developing biomaterials and scaffolds for tissue repair and regeneration. SFRP4 has also been investigated for its potential role in bone formation and repair.

Conclusion

In summary, Recombinant Mouse SFRP4 Protein is a valuable tool in scientific research and biotechnology, with a wide range of applications. Its structure, activity