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Recombinant Proteins
Recombinant proteins have revolutionized the field of biotechnology and have become essential tools in various scientific applications. One such recombinant protein is human LGALS13, which has gained significant attention due to its diverse biological activities and potential therapeutic applications. In this article, we will discuss the structure, activity, and application of recombinant human LGALS13.
LGALS13, also known as Galectin-13, is a member of the galectin family of proteins. It is a 135 amino acid protein with a molecular weight of approximately 15 kDa. The recombinant human LGALS13 is produced by cloning and expressing the LGALS13 gene in a suitable host, such as E. coli or mammalian cells.
The recombinant protein has a similar structure to its native form, consisting of a single carbohydrate recognition domain (CRD) that is responsible for its binding to specific carbohydrate structures. It also has a conserved N-terminal domain that is involved in protein-protein interactions.
LGALS13 is a multifunctional protein with various biological activities. One of its main functions is its ability to bind to specific carbohydrate structures, such as N-acetyllactosamine and galactosyl residues. This interaction plays a crucial role in cell adhesion, migration, and signaling processes.
Moreover, recombinant human LGALS13 has been shown to have anti-inflammatory and immunomodulatory properties. It can inhibit the production of pro-inflammatory cytokines and promote the production of anti-inflammatory cytokines, thus regulating the immune response. This activity makes it a potential therapeutic agent for inflammatory diseases.
Additionally, LGALS13 has been found to have anti-tumor effects. It can induce apoptosis, inhibit cell proliferation, and suppress angiogenesis in various cancer cell lines. These properties make it a promising candidate for cancer treatment.
The diverse biological activities of recombinant human LGALS13 make it a valuable tool in many scientific applications. One of its main applications is in the field of cancer research. The anti-tumor effects of LGALS13 make it a potential target for cancer therapy, and its ability to bind to specific carbohydrate structures can be utilized in targeted drug delivery systems.
Furthermore, recombinant human LGALS13 has shown promising results in the treatment of inflammatory diseases. Its anti-inflammatory and immunomodulatory properties make it a potential therapeutic agent for conditions such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
In addition, LGALS13 has been studied for its role in pregnancy and fetal development. It has been found to play a crucial role in placental development and maintenance, making it a potential biomarker for pregnancy complications.
In conclusion, recombinant human LGALS13 is a versatile protein with various biological activities and potential therapeutic applications. Its structure and activity make it a valuable tool in cancer research, inflammatory diseases, and pregnancy complications. With further research and development, recombinant human LGALS13 has the potential to make a significant impact in the field of biotechnology and medicine.
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