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AntibodySystem
Recombinant Proteins
Recombinant Human CXCL10/IP-10 Protein is a highly versatile and potent chemokine that plays a crucial role in various physiological and pathological processes. This protein is produced through recombinant DNA technology, making it a valuable tool for research and therapeutic applications. In this article, we will discuss the structure, activity, and applications of Recombinant Human CXCL10/IP-10 Protein.
Recombinant Human CXCL10/IP-10 Protein is a small protein consisting of 98 amino acids with a molecular weight of approximately 11 kDa. It belongs to the CXC chemokine family and is produced by various cell types, including monocytes, macrophages, and endothelial cells. The protein is composed of three anti-parallel beta strands and one alpha helix, forming a characteristic chemokine fold.
The primary structure of Recombinant Human CXCL10/IP-10 Protein is highly conserved among different species, with 91% amino acid sequence identity between human and mouse proteins. This high level of conservation suggests that the protein plays a critical role in biological processes and is essential for the proper functioning of the immune system.
Recombinant Human CXCL10/IP-10 Protein acts as a potent chemoattractant for various immune cells, including T cells, natural killer cells, and dendritic cells. It exerts its effects by binding to its receptor, CXCR3, which is expressed on the surface of these cells. This interaction triggers a signaling cascade, leading to cell migration towards the site of infection or inflammation.
In addition to its chemotactic activity, Recombinant Human CXCL10/IP-10 Protein also has anti-angiogenic properties. It can inhibit the growth of new blood vessels, which is crucial in controlling tumor growth and metastasis. Moreover, this protein has been shown to have antiviral activity, particularly against viruses such as hepatitis C and HIV.
Due to its diverse biological activities, Recombinant Human CXCL10/IP-10 Protein has numerous potential applications in both research and therapeutics. In research, this protein is commonly used as a chemoattractant to study the migration of immune cells in various disease models. It is also used to investigate the role of CXCL10/IP-10 in immune responses and inflammation.
In therapeutics, Recombinant Human CXCL10/IP-10 Protein has shown promising results in the treatment of various diseases. Its anti-angiogenic properties make it a potential candidate for cancer therapy, especially in combination with other chemotherapeutic agents. This protein has also been studied for its potential use in the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, due to its ability to regulate immune cell migration.
Moreover, Recombinant Human CXCL10/IP-10 Protein has been investigated as a potential biomarker for various diseases. Its levels have been found to be elevated in conditions such as viral infections, autoimmune diseases, and certain types of cancer. This makes it a valuable tool for disease diagnosis and monitoring.
In summary, Recombinant Human CXCL10/IP-10 Protein is a highly versatile chemokine with diverse biological activities. Its structure, activity, and potential applications make it a valuable tool for both research and therapeutics. As our understanding of this protein continues to grow, it is likely to have even more significant implications in the field of medicine.
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