Adalimumab Biosimilar – Anti-TNF alpha mAb – Research Grade

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Product nameAdalimumab Biosimilar - Anti-TNF alpha mAb - Research Grade
SourceDrugBank DB00051
SpeciesHuman
Expression systemMammalian
Molecular weight144kDa
Purity>85%
BufferPBS pH7.5
Delivery conditionBlue ice (+4°)
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Delivery Time3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term; -20°C for long term
BrandProteoGenix
ApplicationsELISA,WB
Aliases /SynonymsAdalimumab,Adalimumab,TNF alpha,anti-TNF alpha
ReferencePX-TA1001
NoteFor research use only. Not suitable for human use.
IsotypeIgG1
ClonalityMonoclonal Antibody

Description of Adalimumab Biosimilar - Anti-TNF alpha mAb - Research Grade

Adalimumab is a human IgG1 monoclonal antibody that is recombinant and that targets against tumor necrosis factor-alpha (TNF-alpha). This antibody has immunomodulating properties. Adalimumab attaches to TNF-alpha, effectively blocking its interaction with the p55 and p75 TNF cell surface receptors, consequently hindering TNF-mediated immune reactions. TNF-alpha, is an inflammatory cytokine. It is especially involved in autoimmune conditions.

Adalimumab Biosimilar - Anti-TNF alpha mAb binds to Human TNFa/TNF-alpha in indirect ELISA Assay

Immobilized Human TNFa Recombinant Protein (cat. No. PX-P3058) at 0.5µg/mL (100µL/well) can bind Adalimumab Biosimilar - Anti-TNF alpha mAb (cat. No. PX-TA1001) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 142.1M.

SDS-PAGE for Adalimumab Biosimilar - Anti-TNF alpha mAb

Adalimumab Biosimilar - Anti-TNF alpha mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.

Reviews

  • Ofer Gover

    We used this ab to reduce as a negative control for reducing caco-2 (IEC) cells exitation by exugenues TNFa. We measured IL8 secreation as a result of TNFa stimulation. 1ug/mL ofAdalimumab Biosimilar – Anti-TNF alpha mAb was enough to completly abolish IL8 secreation by TNFa stimulation in caco-2 cells.

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