Human CD172a-SIRPA recombinant protein

Description of Human CD172a-SIRPA recombinant protein

General information on Human CD172a-SIRPA recombinant protein

Structure

Human CD172a-SIRPA recombinant protein is a type I transmembrane glycoprotein composed of two extracellular Ig-like domains, a transmembrane domain, and a short cytoplasmic tail. It is encoded by the SHPS-1 gene.

Activity

CD172a-SIRPA protein is a member of the immunoglobulin superfamily that is involved in the regulation of cell-cell interactions. It is known to bind to the CD47 receptor on other cells and inhibit their activation, making it an important immune checkpoint protein.

Application

CD172a-SIRPA recombinant protein has potential applications in the development of antibody-drug conjugates (ADCs) for cancer therapy. It can be used to target cancer cells by binding to CD47 receptors on their surface. This binding triggers an immune response that leads to the destruction of the cancer cells.