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Human eIF4G Recombinant Protein

Reference:
size

100ug, 50ug
Brand

ProteoGenix
Product type

Recombinant Proteins
Host Species

Escherichia coli (E. coli)
Applications

Elisa, WB
Specification
Documents
Publications
Reviews
Product nameHuman eIF4G Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemProkaryotic expression
SequenceMGSHHHHHHSGMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLAESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANK
Molecular weight23.49kDa
Protein delivered with Tag?N-ter His&Trx Tag
Purity estimated≥95%
BufferPBS, imidazole 200mM + 50% glycérol
Formliquid
Delivery conditionDry Ice
Delivery lead time in business days2-3
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
Fragment TypeGlu557~Lys646
Protein AccessionEAW78268.1
NCBI ReferenceWP_001583586
Aliases /SynonymsEIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
ReferencePX-P2069
NoteFor research use only
Datasheet Download
MSDS Download

Publication

  • 1: Nichols N, Bras JM, Hernandez DG, Jansen IE, Lesage S, Lubbe S, Singleton AB; _x000D_ International Parkinson's Disease Genomics Consortium.. EIF4G1 mutations do not_x000D_ cause Parkinson's disease. Neurobiol Aging. 2015 Aug;36(8):2444.e1-4. doi:_x000D_ 10.1016/j.neurobiolaging.2015.04.017. Epub 2015 May 9. PubMed PMID: 26022768;_x000D_ PubMed Central PMCID: PMC4464946.
    • _x000D_ _x000D_ _x000D_
  • 2: Deng H, Wu Y, Jankovic J. The EIF4G1 gene and Parkinson's disease. Acta Neurol_x000D_ Scand. 2015 Aug;132(2):73-8. doi: 10.1111/ane.12397. Epub 2015 Mar 13. Review._x000D_ PubMed PMID: 25765080.
    • _x000D_ _x000D_ _x000D_
  • 3: Huttenlocher J, Krüger R, Capetian P, Lohmann K, Brockmann K, Csoti I, Klein_x000D_ C, Berg D, Gasser T, Bonin M, Riess O, Bauer P. EIF4G1 is neither a strong nor a _x000D_ common risk factor for Parkinson's disease: evidence from large European cohorts._x000D_ J Med Genet. 2015 Jan;52(1):37-41. doi: 10.1136/jmedgenet-2014-102570. Epub 2014 _x000D_ Nov 3. PubMed PMID: 25368108.
    • _x000D_ _x000D_ _x000D_
  • 4: Akabayov SR, Akabayov B, Wagner G. Human translation initiation factor eIF4G1 _x000D_ possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A_x000D_ in the eIF4G/eIF4A complex. Biochemistry. 2014 Oct 21;53(41):6422-5. doi:_x000D_ 10.1021/bi500600m. Epub 2014 Oct 8. PubMed PMID: 25255371; PubMed Central PMCID: _x000D_ PMC4204880.
    • _x000D_ _x000D_ _x000D_
  • 5: Attar-Schneider O, Drucker L, Zismanov V, Tartakover-Matalon S, Lishner M._x000D_ Targeting eIF4GI translation initiation factor affords an attractive therapeutic _x000D_ strategy in multiple myeloma. Cell Signal. 2014 Sep;26(9):1878-87. doi:_x000D_ 10.1016/j.cellsig.2014.05.005. Epub 2014 May 9. PubMed PMID: 24815186.
    • _x000D_ _x000D_ _x000D_
  • 6: Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y,_x000D_ Kuzuhara S, Kachergus JM, Cobb SA, Takahashi H, Mizuno Y, Farrer MJ, Ross OA,_x000D_ Hattori N. EIF4G1 gene mutations are not a common cause of Parkinson's disease in_x000D_ the Japanese population. Parkinsonism Relat Disord. 2014 Jun;20(6):659-61. doi:_x000D_ 10.1016/j.parkreldis.2014.03.004. Epub 2014 Mar 18. PubMed PMID: 24704100; PubMed_x000D_ Central PMCID: PMC4034257.
    • _x000D_ _x000D_ _x000D_
  • 7: Blanckenberg J, Ntsapi C, Carr JA, Bardien S. EIF4G1 R1205H and VPS35 D620N_x000D_ mutations are rare in Parkinson's disease from South Africa. Neurobiol Aging._x000D_ 2014 Feb;35(2):445.e1-3. doi: 10.1016/j.neurobiolaging.2013.08.023. Epub 2013 Sep_x000D_ 27. PubMed PMID: 24080171.
    • _x000D_ _x000D_ _x000D_
  • 8: Li K, Tang BS, Guo JF, Lou MX, Lv ZY, Liu ZH, Tian Y, Song CY, Xia K, Yan XX. _x000D_ Analysis of EIF4G1 in ethnic Chinese. BMC Neurol. 2013 Apr 26;13:38. doi:_x000D_ 10.1186/1471-2377-13-38. PubMed PMID: 23617574; PubMed Central PMCID: PMC3663786.
    • _x000D_ _x000D_ _x000D_
  • 9: Yuan L, Song Z, Xu H, Gu S, Zhu A, Gong L, Zhao Y, Deng H. EIF4G1 Ala502Val_x000D_ and Arg1205His variants in Chinese patients with Parkinson disease. Neurosci_x000D_ Lett. 2013 May 24;543:69-71. doi: 10.1016/j.neulet.2013.02.056. Epub 2013 Apr 2. _x000D_ PubMed PMID: 23562511.
    • _x000D_ _x000D_ _x000D_
  • 10: Siitonen A, Majounie E, Federoff M, Ding J, Majamaa K, Singleton AB._x000D_ Mutations in EIF4G1 are not a common cause of Parkinson's disease. Eur J Neurol. _x000D_ 2013 Apr;20(4):e59. doi: 10.1111/ene.12051. PubMed PMID: 23490116.
    • _x000D_ _x000D_ _x000D_
  • 11: Dobrikov MI, Dobrikova EY, Gromeier M. Dynamic regulation of the translation _x000D_ initiation helicase complex by mitogenic signal transduction to eukaryotic_x000D_ translation initiation factor 4G. Mol Cell Biol. 2013 Mar;33(5):937-46. doi:_x000D_ 10.1128/MCB.01441-12. Epub 2012 Dec 21. PubMed PMID: 23263986; PubMed Central_x000D_ PMCID: PMC3623071.
    • _x000D_ _x000D_ _x000D_
  • 12: Fujioka S, Sundal C, Strongosky AJ, Castanedes MC, Rademakers R, Ross OA,_x000D_ Vilariño-Güell C, Farrer MJ, Wszolek ZK, Dickson DW. Sequence variants in_x000D_ eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with_x000D_ Lewy body dementia. Acta Neuropathol. 2013 Mar;125(3):425-38. doi:_x000D_ 10.1007/s00401-012-1059-4. Epub 2012 Nov 4. PubMed PMID: 23124435; PubMed Central_x000D_ PMCID: PMC3580022.
    • _x000D_ _x000D_ _x000D_
  • 13: Badura M, Braunstein S, Zavadil J, Schneider RJ. DNA damage and eIF4G1 in_x000D_ breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proc_x000D_ Natl Acad Sci U S A. 2012 Nov 13;109(46):18767-72. doi: 10.1073/pnas.1203853109. _x000D_ Epub 2012 Oct 29. PubMed PMID: 23112151; PubMed Central PMCID: PMC3503184.
    • _x000D_ _x000D_ _x000D_
  • 14: Zhao Y, Ho P, Prakash KM, Foo JN, Liu JJ, Au WL, Tan LC, Tan EK. Analysis of _x000D_ EIF4G1 in Parkinson's disease among Asians. Neurobiol Aging. 2013_x000D_ Apr;34(4):1311.e5-6. doi: 10.1016/j.neurobiolaging.2012.09.003. Epub 2012 Oct 23._x000D_ PubMed PMID: 23092605.
    • _x000D_ _x000D_ _x000D_
  • 15: Kumar KR, Lohmann K, Klein C. Genetics of Parkinson disease and other_x000D_ movement disorders. Curr Opin Neurol. 2012 Aug;25(4):466-74. doi:_x000D_ 10.1097/WCO.0b013e3283547627. Review. PubMed PMID: 22772876.
    • _x000D_ _x000D_ _x000D_
  • 16: Schulte EC, Mollenhauer B, Zimprich A, Bereznai B, Lichtner P, Haubenberger_x000D_ D, Pirker W, Brücke T, Molnar MJ, Peters A, Gieger C, Trenkwalder C, Winkelmann_x000D_ J. Variants in eukaryotic translation initiation factor 4G1 in sporadic_x000D_ Parkinson's disease. Neurogenetics. 2012 Aug;13(3):281-5. doi:_x000D_ 10.1007/s10048-012-0334-9. Epub 2012 Jun 16. PubMed PMID: 22707335.
    • _x000D_ _x000D_ _x000D_
  • 17: Lesage S, Condroyer C, Klebe S, Lohmann E, Durif F, Damier P, Tison F, Anheim_x000D_ M, Honoré A, Viallet F, Bonnet AM, Ouvrard-Hernandez AM, Vidailhet M, Durr A,_x000D_ Brice A; French Parkinson's Disease Genetics Study Group.. EIF4G1 in familial_x000D_ Parkinson's disease: pathogenic mutations or rare benign variants? Neurobiol_x000D_ Aging. 2012 Sep;33(9):2233.e1-2233.e5. doi: 10.1016/j.neurobiolaging.2012.05.006._x000D_ Epub 2012 Jun 1. PubMed PMID: 22658323.

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