Human RORC recombinant protein

Description of Human RORC recombinant protein

Introduction to Human RORC Recombinant Protein

Human RORC (Retinoic Acid Receptor-Related Orphan Receptor C) is a member of the nuclear receptor superfamily of transcription factors. It plays an important role in the regulation of immune cell development, differentiation, and function. The recombinant form of this protein, also known as RORC recombinant protein, is a valuable tool for studying its structure, activity, and potential applications as a drug target.

Structure of Human RORC Recombinant Protein

The human RORC protein is composed of 530 amino acids and has a molecular weight of approximately 60 kDa. It contains two functional domains: a DNA-binding domain and a ligand-binding domain. The DNA-binding domain is responsible for binding to specific DNA sequences, while the ligand-binding domain is involved in regulating the activity of the protein.

Activity of Human RORC Recombinant Protein

Human RORC is primarily expressed in immune cells, such as T cells, B cells, and natural killer cells. It plays a crucial role in the development and function of these cells. RORC regulates the expression of genes involved in the differentiation of immune cells, as well as the production of cytokines and other immune molecules.

Studies have shown that RORC is a key regulator of Th17 cells, a subset of T cells that are involved in the immune response against pathogens. It promotes the differentiation of naïve T cells into Th17 cells by activating the expression of genes involved in Th17 cell development. Additionally, RORC also regulates the production of IL-17, a pro-inflammatory cytokine produced by Th17 cells.

In addition to its role in immune cell development and function, RORC has also been implicated in other biological processes, such as lipid metabolism and circadian rhythm regulation. Its activity is regulated by various factors, including retinoic acid, a metabolite of vitamin A, and cholesterol metabolites.

Applications of Human RORC Recombinant Protein

Given its important role in immune cell function, RORC has emerged as a potential drug target for various diseases, including autoimmune disorders and cancer. Inhibiting RORC activity could potentially suppress the production of pro-inflammatory cytokines and reduce the activity of Th17 cells, which are involved in the pathogenesis of autoimmune diseases.

In fact, several studies have shown that targeting RORC with small molecule inhibitors or antibodies can effectively suppress Th17 cell activity and reduce inflammation in animal models of autoimmune diseases, such as multiple sclerosis and psoriasis. These findings suggest that RORC recombinant protein could be used as a valuable tool for developing new therapies for these diseases.

Furthermore, RORC has also been identified as a potential target in cancer immunotherapy. Th17 cells have been shown to play a role in anti-tumor immune responses, and targeting RORC could enhance the activity of these cells and improve their anti-tumor function. RORC recombinant protein could be used to study the mechanisms involved in this process and potentially aid in the development of new cancer immunotherapies.

Conclusion

In summary, human RORC recombinant protein is a valuable tool for studying the structure and activity of this important transcription factor. Its role in immune cell development and function makes it a potential drug target for various diseases, including autoimmune disorders and cancer. Further research on RORC and its recombinant form could lead to the development of new and effective therapies for these diseases.