Recombinant Human KATNA1, N-His

Description of Recombinant Human KATNA1, N-His

Introduction

Recombinant Human KATNA1, N-His is a protein that plays a crucial role in cellular processes such as cell division and cytoskeleton organization. It is also known as Katanin p60 subunit A-like 1, and is encoded by the KATNA1 gene. This protein has been extensively studied for its structure, activity, and potential applications as a drug target. In this article, we will delve into the details of Recombinant Human KATNA1, N-His and its significance in the field of biomedical research.

Structure of Recombinant Human KATNA1, N-His

Recombinant Human KATNA1, N-His is a 60 kDa protein that belongs to the AAA (ATPases associated with diverse cellular activities) family. It is composed of 546 amino acids and has a conserved ATPase domain, which is essential for its activity. The crystal structure of Recombinant Human KATNA1, N-His has been determined, revealing a hexameric ring structure with a central pore. This structure is similar to other members of the AAA family, indicating a common mechanism of action.

Activity of this protein

Recombinant Human KATNA1, N-His is a microtubule-severing protein that plays a crucial role in regulating microtubule dynamics. It uses the energy from ATP hydrolysis to sever and disassemble microtubules, which are essential for various cellular processes such as cell division, cell migration, and intracellular transport. This activity is crucial for maintaining the proper organization and function of the cytoskeleton.

Role as a Drug Target

The dysregulation of microtubule dynamics has been linked to various diseases, including cancer and neurodegenerative disorders. As Recombinant Human KATNA1, N-His plays a crucial role in regulating microtubule dynamics, it has emerged as a potential drug target for these diseases. In fact, several studies have shown that inhibiting the activity of Recombinant Human KATNA1, N-His can lead to the suppression of tumor growth and the improvement of neurodegenerative symptoms.

Cancer

Recombinant Human KATNA1, N-His has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression has been linked to the abnormal organization of the mitotic spindle, which is essential for cell division. Inhibiting the activity of Recombinant Human KATNA1, N-His has been shown to disrupt the mitotic spindle and induce cell death in cancer cells, making it a promising target for cancer therapy.

Neurodegenerative Disorders

The proper organization and function of microtubules are crucial for maintaining the structure and function of neurons. Disruptions in microtubule dynamics have been implicated in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Studies have shown that inhibiting the activity of Recombinant Human KATNA1, N-His can improve the symptoms of these diseases by restoring microtubule dynamics.

Conclusion

In summary, Recombinant Human KATNA1, N-His is a 60 kDa protein that plays a crucial role in regulating microtubule dynamics. Its dysregulation has been linked to various diseases, making it a potential drug target for cancer and neurodegenerative disorders. The determination of its crystal structure has provided insights into its mechanism of action, and ongoing research is focused on developing inhibitors targeting this protein. The potential applications of Recombinant Human KATNA1, N-His in the field of biomedicine make it a promising area of study for future research.