Recombinant Human NCF2, N-His

Reference: YHD36201
Product nameRecombinant Human NCF2, N-His
Uniprot IDP19878
Origin speciesHomo sapiens (Human)
Expression systemProcaryotic expression
Protein delivered with Tag?N-Terminal His Tag
Buffer0.01M PBS, pH 7.4.
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Aliases /SynonymsNeutrophil NADPH oxidase factor 2, NOXA2, p67-phox, NADPH oxidase activator 2, 67 kDa neutrophil oxidase factor, Neutrophil cytosol factor 2, NCF-2, NCF2, P67PHOX
NoteFor research use only

Description of Recombinant Human NCF2, N-His


Recombinant Human NCF2, N-His is a protein that plays a crucial role in the immune system and has potential as a drug target for various diseases. In this article, we will discuss the structure, activity, and potential applications of this protein.

Structure of Recombinant Human NCF2, N-His

Recombinant Human NCF2, N-His is a 47 kDa protein that is composed of 390 amino acids. It belongs to the NCF2 family of proteins and is also known as Neutrophil Cytosol Factor 2 or p67phox. The protein is made up of multiple domains, including the N-terminal domain, the central domain, and the C-terminal SH3 domain. These domains are essential for the protein’s function and interact with other proteins in the immune system.

Activity of this protein

Recombinant Human NCF2, N-His is primarily involved in the production of reactive oxygen species (ROS) in immune cells, specifically in neutrophils. It is a critical component of the NADPH oxidase enzyme complex, which is responsible for generating ROS for the immune response. The protein is activated by phosphorylation and translocates to the cell membrane, where it interacts with other proteins to form the active NADPH oxidase complex. This complex is crucial for the killing of pathogens and the regulation of immune responses.

Potential Applications of Recombinant Human NCF2, N-His

Due to its role in the immune system, Recombinant Human NCF2, N-His has potential applications in the treatment of various diseases. One of the most promising areas of research is its potential as a drug target for autoimmune diseases. Autoimmune diseases occur when the immune system mistakenly attacks healthy cells and tissues. By targeting Recombinant Human NCF2, N-His, researchers hope to regulate the production of ROS and prevent excessive immune responses that can lead to autoimmune diseases.

Another potential application of Recombinant Human NCF2, N-His is in the treatment of infectious diseases. As mentioned earlier, the protein is involved in the killing of pathogens through the production of ROS. By targeting this protein, researchers can potentially enhance the immune response against pathogens and improve the body’s ability to fight off infections.

Furthermore, Recombinant Human NCF2, N-His has also been studied in the context of cancer. Some studies have shown that the protein may play a role in the development and progression of certain types of cancer. By understanding its function and interactions with other proteins, researchers hope to develop targeted therapies that can inhibit the activity of Recombinant Human NCF2, N-His and potentially prevent or treat cancer.


In conclusion, Recombinant Human NCF2, N-His is a 47 kDa protein that plays a critical role in the immune system. Its structure and activity make it a promising drug target for autoimmune diseases, infectious diseases, and cancer. Further research on this protein may lead to the development of new and effective treatments for these diseases.


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