Recombinant Human PROS1, N-His

Reference: YHC24001
Product nameRecombinant Human PROS1, N-His
Uniprot IDP07225
Origin speciesHomo sapiens (Human)
Expression systemProcaryotic expression
Protein delivered with Tag?N-Terminal His Tag
Buffer0.01M PBS, pH 7.4.
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Aliases /SynonymsPROS1, Vitamin K-dependent protein S, PROS
NoteFor research use only

Description of Recombinant Human PROS1, N-His


Recombinant Human PROS1, N-His is a protein that has been genetically engineered for use in various medical and scientific applications. This protein is produced using recombinant DNA technology, which involves inserting the gene for PROS1 into a host organism, such as bacteria or yeast, and allowing it to be expressed and purified for use. In this article, we will explore the structure, activity, and potential applications of this important protein.

Structure of Recombinant Human PROS1, N-His

Recombinant Human PROS1, N-His is a glycoprotein, meaning it contains both protein and carbohydrate components. It is composed of 676 amino acids and has a molecular weight of approximately 75 kDa. The protein consists of several domains, including an N-terminal Gla domain, four EGF-like domains, and two C-type lectin-like domains. The N-His tag, which is added during the recombinant production process, allows for easy purification and identification of the protein.

Activity of this protein

The primary function of PROS1 is to act as an anticoagulant and anti-inflammatory protein in the body. It works by binding to activated protein C (APC) and enhancing its activity, which in turn inhibits the formation of blood clots. Additionally, PROS1 has been shown to have anti-inflammatory effects by inhibiting the production of inflammatory cytokines and promoting the production of anti-inflammatory cytokines. This activity makes PROS1 an important regulator of blood clotting and inflammation in the body.

Application as a Drug Target

Due to its role in regulating blood clotting and inflammation, PROS1 has been identified as a potential drug target for various medical conditions. For example, individuals with mutations in the PROS1 gene may have a higher risk of developing venous thrombosis, a condition in which blood clots form in the veins and can lead to serious complications. By targeting PROS1, researchers hope to develop treatments that can prevent or treat venous thrombosis.

In addition to its potential as a drug target, PROS1 has also been studied for its potential use in gene therapy. By delivering a functional PROS1 gene to individuals with mutations, it may be possible to restore proper PROS1 function and prevent or treat conditions related to PROS1 deficiency, such as venous thrombosis.

Other Potential Applications

Aside from its role in regulating blood clotting and inflammation, PROS1 has also been studied for its potential in other medical conditions. For example, studies have shown that PROS1 may have a role in modulating the immune response and could potentially be used in the treatment of autoimmune diseases. Additionally, PROS1 has been shown to have anti-tumor effects, making it a potential target for cancer treatment.

Furthermore, PROS1 has been investigated for its potential in tissue regeneration and wound healing. Studies have shown that PROS1 can promote the growth and differentiation of stem cells, making it a promising candidate for tissue engineering and regenerative medicine.


In summary, Recombinant Human PROS1, N-His is a protein with a diverse range of functions and potential applications. Its structure, activity, and potential as a drug target make it an important molecule in the fields of medicine and biotechnology. Further research and development of PROS1 may lead to new treatments for various medical conditions and contribute to advancements in regenerative medicine.


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