Recombinant Human RAB39B Protein, N-His

Description of Recombinant Human RAB39B Protein, N-His

Introduction

Recombinant Human RAB39B Protein, also known as Ras-related protein Rab-39B, is a member of the small GTPase superfamily. It plays a crucial role in the regulation of intracellular vesicular trafficking and protein transport. This protein is encoded by the RAB39B gene located on chromosome X and is highly expressed in the brain, particularly in the cerebellum and hippocampus. In this article, we will discuss the structure, activity, and application of Recombinant Human RAB39B Protein.

Structure of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein is a 22-kDa protein consisting of 200 amino acids. It belongs to the Ras superfamily of small GTPases and shares structural similarities with other members of the Rab family. The protein has a globular structure with a central core domain surrounded by five α-helices and six β-strands. It also has a flexible C-terminal extension that plays a role in its membrane association and subcellular localization.

Activity of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein is a key regulator of intracellular vesicle trafficking. It functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAB39B interacts with other proteins and mediates the transport of cargo vesicles along the cytoskeleton to their specific destinations. This process is essential for maintaining the proper function of organelles and for the secretion of proteins from cells.

RAB39B also plays a role in the formation of the Golgi complex, which is responsible for sorting and modifying proteins for transport to their final destinations. It interacts with other Rab proteins and effector proteins to regulate the fusion of vesicles with the Golgi membrane. Additionally, RAB39B has been shown to be involved in the regulation of autophagy, a cellular process that degrades and recycles damaged or unnecessary components.

Application of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein has a wide range of applications in both research and clinical settings. One of its main applications is in the study of neurological disorders, as RAB39B mutations have been linked to X-linked intellectual disability and Parkinson’s disease. Recombinant RAB39B protein can be used to investigate the role of this protein in the development and progression of these disorders.

Furthermore, RAB39B has been identified as a potential therapeutic target for cancer treatment. Its overexpression has been observed in several types of cancer, including breast, lung, and colorectal cancer. Inhibiting RAB39B activity could potentially disrupt the transport of proteins and limit the growth and spread of cancer cells.

Recombinant Human RAB39B Protein has also been used in drug discovery and development. By studying the interactions of RAB39B with other proteins and small molecules, researchers can identify potential drug targets and develop new therapies for various diseases.

Conclusion

In summary, Recombinant Human RAB39B Protein is a small GTPase that plays a critical role in intracellular vesicular trafficking and protein transport. Its structure and activity make it a key regulator of organelle function and cellular processes such as autophagy. Its applications in research and medicine make it a valuable tool for understanding and treating various diseases. Further studies on this protein will undoubtedly uncover more of its functions and potential therapeutic uses.