Recombinant Human SLC17A1 Protein, N-His-SUMO

Description of Recombinant Human SLC17A1 Protein, N-His-SUMO

Recombinant Human SLC17A1 Protein, also known as solute carrier family 17 member 1, is a protein that plays a crucial role in the transport of various molecules across cell membranes. This protein is encoded by the SLC17A1 gene and is found in many different tissues and cell types throughout the body. In this article, we will explore the structure, activity, and applications of this important protein.

The Recombinant Human SLC17A1 Protein is a transmembrane protein, meaning it spans the cell membrane and has both an intracellular and extracellular region. It is composed of 12 transmembrane domains, with the N-terminus located in the cytoplasm and the C-terminus located outside of the cell. The protein also contains two conserved motifs, known as the MFS (major facilitator superfamily) and the P-loop, which are important for its transport function.

The structure of this protein is highly conserved among different species, with a 97% amino acid sequence similarity between human and mouse SLC17A1 proteins. This highlights the importance of this protein in various biological processes.

The primary function of Recombinant Human SLC17A1 Protein is to transport small molecules, such as organic anions, across cell membranes. This is achieved through a process known as secondary active transport, where the protein uses the energy from the movement of other molecules to transport its substrate.

One of the main substrates of this protein is urate, a byproduct of purine metabolism. Recombinant Human SLC17A1 Protein is responsible for transporting urate out of cells, helping to maintain healthy levels in the body. Mutations in the SLC17A1 gene have been linked to hyperuricemia, a condition characterized by high levels of urate in the blood.

In addition to urate, Recombinant Human SLC17A1 Protein also transports other important molecules such as ascorbate (vitamin C) and glutamate, an important neurotransmitter in the brain. This highlights the diverse role of this protein in various physiological processes.

The unique structure and function of Recombinant Human SLC17A1 Protein make it a valuable tool in scientific research and medical applications. One of the main applications of this protein is in the study of urate metabolism and its role in diseases such as gout and kidney stones.

Recombinant Human SLC17A1 Protein is also used in drug development, as it is a target for drugs that aim to regulate urate levels. By understanding the structure and activity of this protein, researchers can design more effective and specific drugs to treat conditions related to urate metabolism.

Furthermore, Recombinant Human SLC17A1 Protein has potential therapeutic applications in the treatment of neurological disorders. As it is responsible for transporting glutamate, which plays a crucial role in brain function, this protein has been studied as a potential target for drugs to treat conditions such as Alzheimer’s disease and epilepsy.

In summary, Recombinant Human SLC17A1 Protein is a vital component of various physiological processes and has important applications in scientific research and medicine. Its unique structure and transport activity make it a valuable tool for understanding and treating diseases related to urate metabolism and neurological disorders.