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Arovia
Recombinant Proteins
Recombinant Mouse CD244 Protein, also known as CD244 antigen, is a transmembrane protein that belongs to the signaling lymphocyte activation molecule (SLAM) family. This protein is encoded by the Cd244 gene and is predominantly expressed on the surface of natural killer (NK) cells, CD8+ T cells, and a subset of CD4+ T cells. It plays a crucial role in regulating immune responses and is involved in various cellular processes such as cell proliferation, cytokine production, and cytotoxicity.
The Recombinant Mouse CD244 Protein is a type I transmembrane protein with a molecular weight of approximately 50 kDa. It consists of a single extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain of CD244 contains two immunoglobulin (Ig)-like domains, a variable (V)-type Ig-like domain and a constant (C)-type Ig-like domain. These domains are responsible for the binding of CD244 to its ligands.
The cytoplasmic tail of CD244 contains several conserved tyrosine residues that are involved in signaling. Upon binding to its ligands, CD244 undergoes phosphorylation of these tyrosine residues, leading to the recruitment of signaling molecules and activation of downstream signaling pathways.
The main function of Recombinant Mouse CD244 Protein is to regulate the activity of immune cells. It can act as both an activating and inhibitory receptor, depending on the type of immune cell it is expressed on and the ligand it binds to.
When CD244 is expressed on NK cells, it acts as an activating receptor and promotes NK cell-mediated cytotoxicity against target cells. This is achieved by the binding of CD244 to its ligands, such as CD48 and CD150, on target cells, leading to the activation of NK cells and the release of cytotoxic molecules.
On the other hand, when CD244 is expressed on T cells, it acts as an inhibitory receptor and regulates T cell activation. This is achieved by the binding of CD244 to its ligands, such as CD48 and CD150, on antigen-presenting cells (APCs), leading to the inhibition of T cell proliferation and cytokine production.
Recombinant Mouse CD244 Protein has various applications in both research and clinical settings. One of the main applications of this protein is in the study of immune responses and immune-mediated diseases. By studying the binding of CD244 to its ligands and the downstream signaling pathways, researchers can gain a better understanding of the role of CD244 in regulating immune responses and its potential role in diseases such as cancer and autoimmune disorders.
In addition, Recombinant Mouse CD244 Protein can also be used in the development of immunotherapies. By targeting CD244 and modulating its activity, it is possible to enhance or suppress immune responses, making it a potential target for the treatment of various diseases. Furthermore, the use of CD244-specific antibodies or recombinant proteins can also be used as diagnostic tools for the detection of immune cell activity and dysfunction.
Recombinant Mouse CD244 Protein is a transmembrane protein that plays a crucial role in regulating immune responses. Its structure, activity, and applications make it a valuable protein in the study of immune-mediated diseases and the development of immunotherapies. Further research on this protein may lead to new insights and potential treatments for various diseases.
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