Recombinant Human IGF2BP2, N-His

Description of Recombinant Human IGF2BP2, N-His

Introduction

Recombinant Human IGF2BP2 (insulin-like growth factor 2 mRNA-binding protein 2) is a protein that plays a crucial role in regulating gene expression and cellular growth and survival. It is a member of the IGF2BP family, which also includes IGF2BP1 and IGF2BP3. IGF2BP2 is a 65 kDa protein that is encoded by the IGF2BP2 gene located on chromosome 3 in humans.

Structure of Recombinant Human IGF2BP2

Recombinant Human IGF2BP2 is a single-chain protein consisting of 578 amino acids. It contains four RNA-binding domains (KH domains) and two heterogeneous nuclear ribonucleoprotein K homology domains (KH domains). These domains allow IGF2BP2 to bind to specific RNA sequences and regulate their translation and stability.

Activity of Recombinant Human IGF2BP2

IGF2BP2 is primarily known for its role in regulating the expression of insulin-like growth factor 2 (IGF2), a hormone involved in cell growth and proliferation. It binds to the 5’-untranslated region (UTR) of IGF2 mRNA and enhances its translation, leading to increased levels of IGF2 protein. This, in turn, promotes cell growth and survival.

Apart from IGF2, IGF2BP2 also regulates the expression of other mRNAs involved in cell growth and metabolism, such as insulin receptor (INSR) and glucose transporter 4 (GLUT4). It can also bind to and regulate the stability of non-coding RNAs, such as microRNAs, which play a crucial role in gene expression.

Application of Recombinant Human IGF2BP2

Due to its role in regulating cell growth and metabolism, Recombinant Human IGF2BP2 has been studied for its potential therapeutic applications in various diseases. Here are some of the key areas where it has shown promise:

Diabetes

IGF2BP2 has been implicated in the development of type 2 diabetes. Studies have shown that genetic variations in the IGF2BP2 gene are associated with an increased risk of developing type 2 diabetes. Recombinant Human IGF2BP2 has been studied as a potential target for the treatment of diabetes, with some promising results.

Cancer

IGF2BP2 is overexpressed in various types of cancer, including lung, breast, and colon cancer. It is thought to promote cancer cell growth and survival by regulating the expression of IGF2 and other growth-promoting genes. Recombinant Human IGF2BP2 has been studied as a potential target for cancer treatment, and some preclinical studies have shown promising results.

Neurodegenerative diseases

IGF2BP2 has been linked to the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. It is thought to play a role in the regulation of neuronal growth and survival. Recombinant Human IGF2BP2 has been studied as a potential therapeutic target for these diseases, with some promising results in animal models.

Cardiovascular diseases

IGF2BP2 has been found to be involved in the development of atherosclerosis, a condition where plaque builds up in the arteries, leading to heart disease. It is thought to promote the growth and migration of smooth muscle cells, contributing to plaque formation. Recombinant Human IGF2BP2 has been studied as a potential target for the treatment of atherosclerosis, with some promising results.

Other potential applications

Apart from the above-mentioned diseases, Recombinant Human IGF2BP2 has also been studied for its potential role in other conditions, such as obesity, osteoporosis, and wound healing. However, more research is needed to fully understand its therapeutic potential in these areas.