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View ProductsSize | |
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Brand | |
Product type |
Product name | Recombinant Human CD201/PROCR, N-His |
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Origin species | Human |
Expression system | Prokaryotic expression |
Molecular weight | 24.33 kDa |
Buffer | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Form | Liquid |
Delivery condition | Dry Ice |
Delivery lead time in business days | 3-5 days if in stock; 3-5 weeks if production needed |
Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
Brand | AntibodySystem |
Host species | Escherichia coli (E.coli) |
Fragment Type | Ser18-Ser210 |
Aliases /Synonyms | Endothelial protein C receptor, PROCR, EPCR, APC receptor, Endothelial cell protein C receptor, CD201, Activated protein C receptor |
Reference | YHJ82101 |
Note | For research use only. |
Recombinant Human CD201/PROCR is a protein that plays a crucial role in the coagulation and anti-inflammatory processes of the body. It is also known as Endothelial Protein C Receptor (EPCR) and is encoded by the PROCR gene. This protein is a member of the class of serine proteases and is found on the surface of endothelial cells, which line the inner walls of blood vessels. Recombinant Human CD201/PROCR is a recombinant version of the naturally occurring protein, produced through genetic engineering techniques. In this article, we will discuss the structure, activity and applications of this important protein.
The recombinant version of CD201/PROCR is a glycosylated protein with a molecular weight of approximately 33 kDa. It consists of 235 amino acids and has a similar structure to the naturally occurring protein. The protein is composed of an extracellular domain, a transmembrane domain and a cytoplasmic domain. The extracellular domain is responsible for binding to its ligand, activated protein C (APC), while the cytoplasmic domain is involved in signaling pathways.
The crystal structure of Recombinant Human CD201/PROCR has been studied and it has been found that it has a three-dimensional structure similar to other serine proteases. The protein contains a highly conserved Serine-Proline-Aspartic Acid (SPD) motif, which is essential for its activity. This motif is involved in the cleavage of its substrate, protein C, to form activated protein C (APC).
The main function of Recombinant Human CD201/PROCR is to act as a cofactor for the activation of protein C. Protein C is a natural anticoagulant that inhibits the coagulation process by inactivating factors Va and VIIIa. When protein C is activated by thrombin, it binds to Recombinant Human CD201/PROCR on the surface of endothelial cells, leading to the formation of APC. APC then inactivates factors Va and VIIIa, preventing the formation of blood clots.
In addition to its role in coagulation, Recombinant Human CD201/PROCR also has anti-inflammatory properties. It has been shown to inhibit the production of pro-inflammatory cytokines and chemokines, thereby reducing the inflammatory response in the body. This makes it a potential therapeutic target for various inflammatory diseases.
Recombinant Human CD201/PROCR has a wide range of applications in both research and clinical settings. Its role in coagulation and anti-inflammatory processes makes it a valuable tool for studying various diseases and developing new treatments. Some of the potential applications of this protein include:
Recombinant Human CD201/PROCR has been studied as a potential therapeutic agent for the treatment of thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. Its ability to activate protein C and inhibit coagulation makes it a promising alternative to traditional anticoagulant drugs.
The anti-inflammatory properties of Recombinant Human CD201/PROCR make it a potential treatment for inflammatory diseases, such as sepsis, rheumatoid arthritis and inflammatory bowel disease. Studies have shown that administration of this protein can reduce inflammation and improve outcomes in animal models of these diseases.
Recombinant Human CD201/PROCR can also be used as a diagnostic tool for various diseases. Its levels have been found to be altered in
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