Recombinant Human DCTN6 Protein, N-His

Description of Recombinant Human DCTN6 Protein, N-His

Introduction

Recombinant Human DCTN6 protein, also known as dynactin 6, is a protein that plays a crucial role in cellular processes such as intracellular transport, cell division, and cell signaling. This protein is encoded by the DCTN6 gene and is a member of the dynactin complex, which is involved in the movement of cellular cargo along microtubules. Recombinant Human DCTN6 protein is produced through genetic engineering techniques and has various applications in the field of research and medicine.

Structure of Recombinant Human DCTN6 Protein

Recombinant Human DCTN6 protein is a 50 kDa protein consisting of 460 amino acids. It contains multiple domains, including a N-terminal coiled-coil domain, a central proline-rich domain, and a C-terminal WD40 repeat domain. The N-terminal domain is responsible for the interaction with other proteins, while the central domain is involved in binding to microtubules. The WD40 domain is essential for the formation of the dynactin complex, which is crucial for the proper functioning of DCTN6.

Activity of Recombinant Human DCTN6 Protein

Recombinant Human DCTN6 protein is involved in various cellular processes, mainly through its role in the dynactin complex. This complex acts as a molecular motor and facilitates the movement of cellular cargo along microtubules. DCTN6 is also involved in the regulation of cell division, as it interacts with proteins that are essential for the formation of the mitotic spindle. Additionally, DCTN6 has been found to play a role in cell signaling pathways, particularly in the regulation of the Wnt signaling pathway.

Application of Recombinant Human DCTN6 Protein

Recombinant Human DCTN6 protein has various applications in the field of research and medicine. Its role in intracellular transport makes it a valuable tool for studying cellular processes. Researchers use recombinant DCTN6 protein to investigate the function of the dynactin complex and its involvement in different cellular processes. Additionally, DCTN6 has been linked to certain diseases, such as neurodegenerative disorders, making it a potential therapeutic target.

One of the most significant applications of recombinant DCTN6 protein is in the development of diagnostic tools. DCTN6 has been identified as an antigen in autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. Recombinant DCTN6 protein can be used to develop diagnostic tests for these conditions, allowing for early detection and treatment.

Furthermore, recombinant DCTN6 protein has potential applications in drug development. As mentioned earlier, DCTN6 has been implicated in neurodegenerative diseases. By understanding its role in these conditions, researchers can develop drugs that target DCTN6 and potentially slow down or stop the progression of these diseases.

Conclusion

In summary, Recombinant Human DCTN6 protein is a crucial player in various cellular processes, including intracellular transport, cell division, and cell signaling. Its structure consists of multiple domains that are responsible for its various activities. Recombinant DCTN6 protein has numerous applications in research and medicine, making it a valuable tool for studying cellular processes, developing diagnostic tools, and potentially developing new drugs. Further research on DCTN6 and its role in different diseases may lead to new therapeutic approaches and improve our understanding of cellular processes.