Recombinant Human CD49a/ITGA1/VLA-1 Protein, N-His

Description of Recombinant Human CD49a/ITGA1/VLA-1 Protein, N-His

Introduction

Recombinant Human CD49a/ITGA1/VLA-1 Protein is a cell surface glycoprotein that belongs to the integrin family. It is encoded by the ITGA1 gene and is also known as Very Late Antigen-1 (VLA-1). This protein plays a crucial role in cell adhesion and signaling, making it an important molecule in various biological processes. In this article, we will discuss the structure, activity, and applications of Recombinant Human CD49a/ITGA1/VLA-1 Protein.

Structure of Recombinant Human CD49a/ITGA1/VLA-1 Protein

Recombinant Human CD49a/ITGA1/VLA-1 Protein is composed of two subunits, alpha-1 and beta-1. The alpha-1 subunit is encoded by the ITGA1 gene and consists of a large extracellular domain, a transmembrane domain, and a short cytoplasmic tail. The beta-1 subunit is encoded by the ITGB1 gene and has a similar structure to the alpha-1 subunit. The two subunits are non-covalently linked, forming a heterodimeric protein.

The extracellular domain of Recombinant Human CD49a/ITGA1/VLA-1 Protein contains seven repeats of a conserved sequence known as the von Willebrand factor A domain. This domain is responsible for binding to various ligands, including collagen, laminin, and fibronectin. The transmembrane domain is a hydrophobic region that anchors the protein to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling.

Activity of Recombinant Human CD49a/ITGA1/VLA-1 Protein

Recombinant Human CD49a/ITGA1/VLA-1 Protein is primarily involved in cell adhesion and migration. It mediates the attachment of cells to the extracellular matrix (ECM) by binding to specific ligands. This interaction not only provides structural support but also plays a crucial role in cell signaling. The binding of Recombinant Human CD49a/ITGA1/VLA-1 Protein to ECM proteins can activate various intracellular signaling pathways, such as the PI3K-Akt and MAPK pathways, which control cell survival, proliferation, and differentiation.

Apart from cell adhesion, Recombinant Human CD49a/ITGA1/VLA-1 Protein is also involved in immune responses. It is expressed on the surface of various immune cells, including T cells, B cells, and natural killer cells, and plays a role in their activation and migration. It has been shown to be important in the recruitment of immune cells to sites of inflammation and in the formation of immune synapses between T cells and antigen-presenting cells.

Applications of Recombinant Human CD49a/ITGA1/VLA-1 Protein

Recombinant Human CD49a/ITGA1/VLA-1 Protein has a wide range of applications in both research and clinical settings. Its role in cell adhesion and migration makes it a valuable tool for studying cellular processes such as wound healing, tissue regeneration, and cancer metastasis. In addition, its involvement in immune responses makes it a potential target for immunotherapy and vaccine development.

Recombinant Human CD49a/ITGA1/VLA-1 Protein is also used in drug discovery and development. It can be used as a target for screening potential inhibitors or activators, which can be further developed into therapeutic agents for various diseases. Furthermore, recombinant forms of this protein can be used in cell-based assays to study the effects of drugs on cell adhesion and signaling.

In the clinical setting, Recombinant Human CD49a/ITGA1/VLA-1 Protein has been investigated as a potential biomarker for various diseases. Studies have shown that its expression is altered in certain cancers, such as breast and prostate cancer, and may serve as a prognostic marker or