Therapeutic NANOBODY® proteins

Therapeutic NANOBODY® proteins are single-domain antibody fragments derived from heavy-chain-only antibodies found in camelids. Their small size (~15 kDa), high solubility, and exceptional stability under a wide range of conditions make them powerful tools in therapeutic development. Unlike conventional monoclonal antibodies, NANOBODY® proteins can access hidden or sterically restricted epitopes, allowing them to neutralize targets with higher precision.

NANOBODY® proteins exhibit high affinity and specificity for their targets, ranging from extracellular receptors to intracellular proteins. Their mechanisms include:

• Blocking ligand-receptor interactions
• Neutralizing toxins and viral particles
• Modulating enzyme activity
• Acting as carriers for drug delivery or diagnostics

Due to their robustness, NANOBODY® molecules are ideal for inhalable formulations, topical applications, and even intracellular delivery.

Therapeutic NANOBODY® proteins are transforming life science research and clinical development:

• Oncology: Blocking immune checkpoints (e.g., PD-L1) and targeting tumor-specific antigens
• Infectious diseases: Neutralizing viral proteins, including SARS-CoV-2 spike protein
• Neurodegenerative diseases: Crossing the blood-brain barrier for targeted delivery
• Diagnostics: Imaging agents due to rapid clearance and high tissue penetration

Choosing the right NANOBODY® VHH depends on your project needs. Here are some considerations:

• Define the target (e.g., membrane protein, toxin, intracellular protein)
• Determine the required affinity and epitope specificity
• Consider the final format: naked nanobody, Fc-fusion, or drug conjugate
• Assess delivery route and formulation constraints (e.g., systemic vs. local)
• Validate stability, aggregation profile, and manufacturability

ProteoGenix offers biosimilar NANOBODY® proteins tailored for therapeutic, diagnostic, and research applications. Our expertise ensures seamless integration into your therapeutic development pipeline.

NANOBODY^® or NANOBODIES^® are registered trademarks of Ablynx N.V.