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XtenCHO™ transient expression system

The XtenCHO™ mammalian expression system is a cutting-edge solution tailored for rapid and cost-effective recombinant protein expression. Ideal for small- to medium-scale production and high-throughput screening of drug candidates and… Read more
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    XtenCHO™: Transforming Protein Expression with a Revolutionary Mammalian Expression System

    Overview of XtenCHO™

    The XtenCHO™ mammalian expression system is a cutting-edge solution tailored for rapid and cost-effective recombinant protein expression. Ideal for small- to medium-scale production and high-throughput screening of drug candidates and protein variants, XtenCHO™ delivers unparalleled performance, drawing on 28+ years of experience in protein expression technologies.

    Key Features and Benefits

    1. Unmatched Productivity

    • Achieve up to 10x higher yields than competing systems.*
    • Record-breaking results for IgG-like antibodies (1280 mg/L for Claudiximab), bispecific antibodies (>100mg/L), humanized variants (>200mg/L), and non-antibody proteins like ACE2 (>100mg/L with enzymatic activity).

    2. Extended Transient Gene Expression (TGE)

    • Sustained plasmid retention for 14+ days through efficient transfection.
    • Enhanced plasmid stability and protein expression without additional feeding steps.

    3. Streamlined Workflow

    • Simplified, step-reducing protocols to accelerate production.
    • Backed by strong, responsive technical support.

    4. Exceptional Safety and Quality

    • Viral resistance inherent to CHO cells ensures safer production than HEK cells.
    • Clinical-grade protein folding and human-like post-translational modifications.

    5. Flexibility and Scalability

    • Production volumes ranging from 1mL to 10L to suit diverse research needs.
    • Biopharmaceutical-grade output at a fraction of traditional costs.

    6. Global Availability

    • Ships worldwide within 24 hours.

    Applications in Biopharmaceutical Development

    With over 3500 proteins successfully expressed, XtenCHO™ has demonstrated its power in advancing biopharmaceutical research. Its unparalleled yields, consistency, and cost-effectiveness make it ideal for:
    • Early bioanalysis to detect developability issues and improve success rates in clinical trials.
    • High-throughput testing of drug candidates and protein variants generated through mutagenesis.
    • Production of antibodies and proteins for diagnostics, therapeutics, and structural studies.

    Applications in Life Science Research

    XtenCHO™ also addresses critical challenges in bioassay development across industries such as medicine, food production, and environmental analysis. By replacing hybridoma-based systems with CHO-based expression, XtenCHO™ enables:
    • Superior purity, batch-to-batch consistency, and assay precision.
    • Cost-efficient solutions for large-scale production.
    • Seamless integration into existing workflows.

    Why Choose XtenCHO™?

    CHO-based systems are the cornerstone of successful biopharmaceutical production, with nearly three-quarters of approved drugs relying on them. XtenCHO™ amplifies these advantages, delivering rapid and reliable results that increase your project's success potential. The kit includes:
    • Chemically defined, animal-free expression media for optimal performance.
    • XtenCHO™ Enhancer for boosted expression.
    • Control plasmids for added flexibility and precision.

    Partner with XtenCHO™ Today

    XtenCHO™ combines innovation, efficiency, and scalability to redefine protein expression. Whether for therapeutic development or research applications, XtenCHO™ empowers scientists to achieve their goals with confidence and precision. *Data based on internal studies. Results may vary depending on experimental conditions.

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